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Literature summary for 2.7.11.1 extracted from

  • Graves, P.R.; Haas, D.W.; Hagedorn, C.H.; DePaoli-Roach, A.A.; Roach, P.J.
    Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis (1993), J. Biol. Chem., 268, 6394-6401.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
heparin with the peptide substrate DDDDVASLPGLRRR, 4-5fold activation of recombinant casein kinase I delta, half-maximal activation at 0.0095 mg/ml. A truncated form of casein kinase I delta, lacking the COOH-terminal 111 amino acids, is no longer activated by heparin Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus
expression in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
CKI-7 half-maximally at 0.0112 mM Rattus norvegicus
heparin inhibition of recombinant casein kinase I delta when phosvitin is the substrate Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
49121
-
 x * 49121, calculation from nucleotide sequence Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q06486
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + casein
-
 Rattus norvegicus ADP + phosphorylated casein
-
 ?
ATP + DDDDVASLPGLRRR
-
 Rattus norvegicus ADP + ?
-
 ?
ATP + phosvitin
-
 Rattus norvegicus ADP + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 49121, calculation from nucleotide sequence Rattus norvegicus

Synonyms

Synonyms Comment Organism
casein kinase I, delta isoform
-
 Rattus norvegicus