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Literature summary for 2.7.11.1 extracted from
- Linkage of ATM to cell cycle regulation by the Chk2 protein kinase (1998), Science, 282, 1893-1897.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage, the response to DNA damage occurrs in an ataxia telangiectasia mutated ATM-dependent manner | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | ? | - |
? |  |
| additional information | Mus musculus | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O96017 | - |
- |
| Mus musculus | Q9Z265 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage | Homo sapiens |
| phosphoprotein | Chk2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Cdc25C | Chk2 phosphorylated Cdc25C on Ser216 | Homo sapiens | ADP + ? | - |
? | |
| ATP + Cdc25C | phosphorylated Cdc25C on Ser216 | Mus musculus | ADP + phosphorylated Cdc25C | - |
? | |
| additional information | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | Homo sapiens | ? | - |
? | |
| additional information | in response to DNA damage and DNA replicational stress, Chk1 and Chk2 may phosphorylate Cdc25C to prevent entry into mitosis | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine/threonine-protein kinase Chk2 | - |
Homo sapiens |
| serine/threonine-protein kinase Chk2 | - |
Mus musculus |
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