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Literature summary for 2.7.11.1 extracted from

  • Sanchez, Y.; Wong, C.; Thoma, R.S.; Richman, R.; Wu, Z.; Piwnica-Worms, H.; Elledge, S.J.
    Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 (1997), Science, 277, 1497-1501.
    View publication on PubMed
Search for more literature for 2.7.11.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus
-
 ?
-
 ?
additional information Homo sapiens in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14757
-
-
Mus musculus O35280
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Mus musculus ?
-
 ?
additional information in response to DNA damage, Chk1 phosphorylates and inhibits Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and mitotic entry Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Chk1
-
 Homo sapiens
serine/threonine-protein kinase Chk1
-
 Homo sapiens
serine/threonine-protein kinase Chk1
-
 Mus musculus