Literature summary for 2.7.11.1 extracted from

Burnett, P.E.; Blackshaw, S.; Lai, M.M.; Qureshi, I.A.; Burnett, A.F.; Sabatini, D.M.; Snyder, S.H.
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton (1998), Proc. Natl. Acad. Sci. USA, 95, 8351-8356.

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Activating Compound

Activating Compound	Comment	Organism	Structure
neurabin	by way of its PDZ domain, the neuronal-specific neurabin may target p70(S6k) to nerve terminals	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + S6 protein of the 40s ribosomal subunit	Rattus norvegicus	the mitogen-activated protein kinase plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-kDa FK506 binding protein target 1	ADP + phosphorylated S6 protein of the 40s ribosomal subunit	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P67999	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + S6 protein of the 40s ribosomal subunit	the mitogen-activated protein kinase plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes the 12-kDa FK506 binding protein and includes rapamycin and the 12-kDa FK506 binding protein target 1	Rattus norvegicus	ADP + phosphorylated S6 protein of the 40s ribosomal subunit	-	?

Synonyms

Synonyms	Comment	Organism
p70 S6 kinase	-	Rattus norvegicus
p70(S6k)	-	Rattus norvegicus
ribosomal protein S6 kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)