Literature summary for 2.7.11.1 extracted from

Leong, M.L.; Maiyar, A.C.; Kim, B.; O'Keeffe, B.A.; Firestone, G.L.
Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells (2003), J. Biol. Chem., 278, 5871-5882.

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Protein Variants

Protein Variants	Comment	Organism
T256A	the conditional IPTG inducible expression of wild type Sgk, but not of the kinase dead mutant T256A Sgk, protects Con8 mammary epithelial tumor cells from serum starvation-induced apoptosis	Mus musculus
T256A/S422A	unlike the wild-type enzyme the phosphorylation site mutant has no effect on cell survival	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	induction of enzymatically active Sgk functions as a key cell survival component in response to different environmental stress stimuli	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9WVC6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	induction of enzymatically active Sgk functions as a key cell survival component in response to different environmental stress stimuli	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
protein kinase Sgk	-	Mus musculus
serine/threonine-protein kinase Sgk	-	Mus musculus

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Release 2023.1 (January 2023)