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Literature summary for 2.7.10.2 extracted from

  • Aleem, S.U.; Craddock, B.P.; Miller, W.T.
    Constitutive activity in an ancestral form of Abl tyrosine kinase (2015), PLoS ONE, 10, e0131062.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Spodoptera frugiperda (Sf9) cells Monosiga brevicollis

Inhibitors

Inhibitors Comment Organism Structure
BIRB-796 about 60% residual activity at 0.02 mM Monosiga brevicollis
dasatinib about 3% residual activity at 0.02 mM Monosiga brevicollis
DSA-1 about 10% residual activity at 0.02 mM Monosiga brevicollis
DSA-8 about 20% residual activity at 0.02 mM Monosiga brevicollis
imatinib about 80% residual activity at 0.02 mM Monosiga brevicollis
MC25a about 65% residual activity at 0.02 mM Monosiga brevicollis
nilotinib about 70% residual activity at 0.02 mM Monosiga brevicollis
sorafenib about 30% residual activity at 0.02 mM Monosiga brevicollis
VX-680 about 5% residual activity at 0.02 mM Monosiga brevicollis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.29
-
ATP at pH 7.5 and 30°C Monosiga brevicollis

Organism

Organism UniProt Comment Textmining
Monosiga brevicollis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Monosiga brevicollis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + EAIYAAPFAKKKG
-
Monosiga brevicollis ADP + EAI-pY-AAPFAKKKG
-
?

Synonyms

Synonyms Comment Organism
ABL2
-
Monosiga brevicollis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.37
-
ATP at pH 7.5 and 30°C Monosiga brevicollis