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Literature summary for 2.7.10.2 extracted from

  • Baldwin, G.S.; Lio, D.S.; Ferrand, A.; Catimel, B.; Shehan, B.P.; Norton, R.S.; Cheng, H.C.
    Activation of Src family tyrosine kinases by ferric ions (2014), Biochim. Biophys. Acta, 1844, 487-496.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Fe3+ Lyn or Hck kinases in the unphosphorylated active state are significantly inhibited by Fe3+ ion Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe3+ when Lyn or Hck kinases, which have been stabilised in the inactive state by phosphorylation of the C-terminal regulatory tyrosine, are incubated with Fe3+ ions, a significant enhancement of kinase activity is observed Homo sapiens
additional information not activated by Ca2+, Zn2+ or Bi3+ ions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?
ATP + [[Lys19]Cdc2-(6-20) peptide]-L-tyrosine i.e. KVEKIGEGTYGVVKK Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
HCK
-
Homo sapiens
Lyn
-
Homo sapiens
SFK
-
Homo sapiens