Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | Lyn or Hck kinases in the unphosphorylated active state are significantly inhibited by Fe3+ ion | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | when Lyn or Hck kinases, which have been stabilised in the inactive state by phosphorylation of the C-terminal regulatory tyrosine, are incubated with Fe3+ ions, a significant enhancement of kinase activity is observed | Homo sapiens | |
additional information | not activated by Ca2+, Zn2+ or Bi3+ ions | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + [[Lys19]Cdc2-(6-20) peptide]-L-tyrosine | i.e. KVEKIGEGTYGVVKK | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCK | - |
Homo sapiens |
Lyn | - |
Homo sapiens |
SFK | - |
Homo sapiens |