Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Homo sapiens | - |
pancreatic cancer cell | isoform c-Src and Notch-1 co-localize in tissues of pancreatic cancer patients | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
C-SRC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Notch-1-Furin interaction is regulated by the non-receptor tyrosine kinase, c-Src. c-Src and Notch-1 are physically associated, and this association is responsible for Notch-1 processing and activation. Growth factor TGF-alpha, an epidermal growth factor receptor ligand, and PDGF-BB, a platelet derived growth factor receptor ligand, induce the Notch-1-Furin interaction mediated by c-Src. The association between Notch-1 and Furin is a well-regulated process, extracellular growth factor signals regulate this interaction, which is mediated by c-Src, and there is cross-talk between the plasma growth factor receptor-c-Src and Notch pathways | Homo sapiens |