Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | Src family kinases are important for a balanced production of inflammatory cytokines by human monocyte-derived dendritic cells upon stimulation of toll-like receptors TLR3 and TLR8 with their respective agonists. Disruption of this equilibrium through pharmacological inhibition of Src kinases alters the dendritic cell maturation pattern. While expression of interleukin IL-12 and other inflammatory cytokines depends on Src kinases, the induction of IL-23 and co-stimulatory molecules does not. Dendritic cells treated with Src inhibitors are not compromised in their ability to induce CD4 T cell proliferation and to promote the T helper cell Th17 subset survival but are less efficient in inducing T helper cell Th1 differentiation | Homo sapiens |