Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine | application completely abolishes thrombin-induced non-capacitative cation entry into platelets, a Ca2+ entry pathway that is independent of Ca2+ store depletion. Src family tyrosine kinase activation is a required step in non-capacitative cation entry activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | Src family tyrosine kinase activation is a required step in non-capacitative cation entry activation. Application of specific inhibitor 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine completely abolishes thrombin-induced non-capacitative cation entry into platelets, a Ca2+ entry pathway that is independent of Ca2+ store depletion | Homo sapiens |