Literature summary for 2.7.10.2 extracted from

Ghoreschi, K.; Laurence, A.; OShea, J.J.
Janus kinases in immune cell signaling (2009), Immunol. Rev., 228, 273-287.

Protein Variants

Protein Variants	Comment	Organism
V617F	the mutation within the JH2 pseudokinase domain of Jak2 is present in almost all patients with polycythemia vera, as well as high percentages also in patients with essential thrombocythemia, and idiopathic myelofibrosis	Mus musculus
V617F	the mutation within the JH2 pseudokinase domain of Jak2 is present in almost all patients with polycythemia vera, as well as high percentages also in patients with essential thrombocythemia, and idiopathic myelofibrosis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism
CP-690 550	Jak3 and Jak2 inhibitor	Homo sapiens
CP-690 550	Jak3 and Jak2 inhibitor	Mus musculus
dasatinib	Jak2 inhibitor, at high doses (0.001 mM), dasatinib can inhibit Jak2 activity in vitro	Homo sapiens
dasatinib	Jak2 inhibitor, at high doses (0.001 mM), dasatinib can inhibit Jak2 activity in vitro	Mus musculus
INCB018424	Jak2 inhibitor	Homo sapiens
INCB018424	Jak2 inhibitor	Mus musculus
lestaurtinib	Jak2 inhibitor	Homo sapiens
lestaurtinib	Jak2 inhibitor	Mus musculus
PNU156804	Jak3 inhibitor	Homo sapiens
PNU156804	Jak3 inhibitor	Mus musculus
SB1518	Jak2 inhibitor	Homo sapiens
SB1518	Jak2 inhibitor	Mus musculus
TG101348	Jak2 inhibitor	Homo sapiens
TG101348	Jak2 inhibitor	Mus musculus
tyrphostin AG490	Jak3 inhibitor	Homo sapiens
tyrphostin AG490	Jak3 inhibitor	Mus musculus
WHI-P131	Jak3 inhibitor	Homo sapiens
WHI-P131	Jak3 inhibitor	Mus musculus
WHI-P154	Jak3 inhibitor	Homo sapiens
WHI-P154	Jak3 inhibitor	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + a [protein]-L-tyrosine	Mus musculus	-	ADP + a [protein]-L-tyrosine phosphate	-	?
ATP + a [protein]-L-tyrosine	Homo sapiens	-	ADP + a [protein]-L-tyrosine phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a [protein]-L-tyrosine	-	Mus musculus	ADP + a [protein]-L-tyrosine phosphate	-	?
ATP + a [protein]-L-tyrosine	-	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Jak1	-	Mus musculus
Jak1	-	Homo sapiens
JAK2	-	Mus musculus
JAK2	-	Homo sapiens
Jak3	-	Mus musculus
Jak3	-	Homo sapiens
Janus kinase	-	Mus musculus
Janus kinase	-	Homo sapiens
non-receptor protein tyrosine kinase	-	Mus musculus
non-receptor protein tyrosine kinase	-	Homo sapiens
Tyk2	-	Mus musculus
Tyk2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus
ATP	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	deficiency of Jak3 or Tyk2 results in defined clinical disorders, a striking phenotype associated with inactivating Jak3 mutations is severe combined immunodeficiency syndrome, whereas mutation of Tyk2 results in autosomal recessive hyperimmunoglobulin E syndrome, complete deletion of Jak1 or Jak2 in the mouse are not compatible with life and do not have counterparts in human disease. Activating mutations of each of the Jaks are found in association with malignant transformation, the most common being gain-of-function mutations of Jak2 in polycythemia vera and other myeloproliferative disorders.	Homo sapiens
malfunction	deficiency of Jak3 or Tyk2 results in defined clinical disorders, a striking phenotype associated with inactivating Jak3 mutations is severe combined immunodeficiency syndrome, whereas mutation of Tyk2 results in autosomal recessive hyperimmunoglobulin E syndrome, complete deletion of Jak1 or Jak2 in the mouse are not compatible with life and do not have counterparts in human disease. Activating mutations of each of the Jaks are found in association with malignant transformation, the most common being gain-of-function mutations of Jak2 in polycythemia vera and other myeloproliferative disorders. Jak1 knockout mice have major deficits in lymphopoiesis and a failure to respond to signals from class II cytokine receptors, gammac cytokine receptors, and cytokine receptors that contain the gp130 subunit. Jak2 deficiency is lethal.	Mus musculus