Protein Variants | Comment | Organism |
---|---|---|
additional information | Tyk2 mutations are associated with autosomal recessive hyperimmunoglobulin E or JobÂ’s syndrome | Homo sapiens |
V617F | JAK2 gain-of-function mutation underlying myeloproliferative diseases | Mus musculus |
V617F | JAK2 gain-of-function mutation underlying myeloproliferative diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CP-690,550 | has nanomolar potency in in vitro JAK2 and JAK3 kinase assays | Homo sapiens | |
CP-690,550 | has nanomolar potency in in vitro JAK2 and JAK3 kinase assays | Mus musculus | |
INCB18424 | Incyte | Homo sapiens | |
INCB18424 | Incyte | Mus musculus | |
XL019 | Exelixis | Homo sapiens | |
XL019 | Exelixis | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for activity | Mus musculus | |
Mg2+ | required for activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Mus musculus | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation | Mus musculus |
phosphoprotein | Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Mus musculus | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JAK2 | - |
Mus musculus |
JAK2 | - |
Homo sapiens |
Jak3 | - |
Mus musculus |
Jak3 | - |
Homo sapiens |
Janus kinase | - |
Mus musculus |
Janus kinase | - |
Homo sapiens |
Tyk2 | - |
Mus musculus |
Tyk2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | mutations of JAK3 may be a cause of severe combined immunodeficiency | Homo sapiens |
malfunction | mutations of JAK3 may be a cause of severe combined immunodeficiency, JAK3 knockout mice have a profound reduction in thymic progenitor cells and reduced ability to reconstitute T cell development, in the periphery, CD8+ T and NK cells are severely reduced. JAK3- (and gamma chain) deficient mice also have severely defective B cell development, deficiency of JAK1 and JAK2 is lethal | Mus musculus |
physiological function | JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23 | Mus musculus |
physiological function | JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23 | Homo sapiens |