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Literature summary for 2.7.10.2 extracted from
- Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening (2008), J. Med. Chem., 51, 4419-4429.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | protein tyrosine kinase inhibitors represent emerging therapeutics for cancer chemoprevention | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the kinase domain of tyrosine kinase c-Src is cloned and expressed using the Bac-to-Bac baculovirus expression system | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| epihematoxylol | - |
Homo sapiens |  |
| haematoxylene | - |
Homo sapiens | |
| haematoxylone | - |
Homo sapiens | |
| hematoxylin | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P12931 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| purified on a Ni-NTA column | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + poly(Glu,Tyr) | substrate used in the tyrosine kinase asssay | Homo sapiens | ? + ADP | - |
? | |
| ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| C-SRC | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
tyrosine kinase assay | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
tyrosine kinase assay | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00036 | - |
- |
Homo sapiens | epihematoxylol | |
| 0.00044 | - |
- |
Homo sapiens | hematoxylin | |
| 0.0016 | - |
- |
Homo sapiens | haematoxylene | |
| 0.0018 | - |
- |
Homo sapiens | haematoxylone | |
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Release 2023.1 (January 2023)
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