Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.2 extracted from

  • Lee, Y.G.; Chain, B.M.; Cho, J.Y.
    Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaBalpha via activation of the phosphoinositide-3-kinase and Akt pathways (2009), Int. J. Biochem. Cell Biol., 41, 811-821.
    View publication on PubMed
Search for more literature for 2.7.10.2

Application

Application Comment Organism
medicine Syk may be a potential target for the development of potent anti-inflammatory drugs Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
piceatannol
-
 Mus musculus
siRNA
-
 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Mus musculus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P48025
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-
peritoneal macrophage
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + KVEKIGEGTYGVVYK substrate peptide used in kinase activity assay, derived from p34cdc2 Mus musculus ? + ADP
-
 ?
ATP + [protein]-L-tyrosine
-
 Mus musculus ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Spleen tyrosine kinase
-
 Mus musculus
Syk
-
 Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 in vitro c-Src kinase activity assay Mus musculus