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Literature summary for 2.7.10.2 extracted from

  • Ikeda, K.; Nakayama, Y.; Togashi, Y.; Obata, Y.; Kuga, T.; Kasahara, K.; Fukumoto, Y.; Yamaguchi, N.
    Nuclear localization of Lyn tyrosine kinase mediated by inhibition of its kinase activity (2008), Exp. Cell Res., 314, 3392-3404.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
into the pcDNA4/TO vector, Lyn118(G2A/C3A)-GFP and Lyn118-GFP are constructed by fusion with GFP obtained from pEGFP-C1 Homo sapiens

Protein Variants

Protein Variants Comment Organism
G2A/C3A mutant lacking the sites for lipid modification Homo sapiens
G2A/C3A/K275A mutant lacking the sites for lipid modification, mutation in the ATP-binding site, kinase-dead Homo sapiens
additional information mutant lacking the SH4 domain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
SU6656
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus accumulation of endogenous Lyn in the nucleus upon treatment with leptomycin B Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
ADP + [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07948
-
-

Purification (Commentary)

Purification (Comment) Organism
nuclei of THP-1 cells are purified Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
Lyn tyrosine kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens