Cloned (Comment) | Organism |
---|---|
into the pcDNA4/TO vector, Lyn118(G2A/C3A)-GFP and Lyn118-GFP are constructed by fusion with GFP obtained from pEGFP-C1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G2A/C3A | mutant lacking the sites for lipid modification | Homo sapiens |
G2A/C3A/K275A | mutant lacking the sites for lipid modification, mutation in the ATP-binding site, kinase-dead | Homo sapiens |
additional information | mutant lacking the SH4 domain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SU6656 | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | accumulation of endogenous Lyn in the nucleus upon treatment with leptomycin B | Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07948 | - |
- |
Purification (Comment) | Organism |
---|---|
nuclei of THP-1 cells are purified | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Lyn tyrosine kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |