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Literature summary for 2.7.10.2 extracted from

  • Shinohara, M.; Koga, T.; Okamoto, K.; Sakaguchi, S.; Arai, K.; Yasuda, H.; Takai, T.; Kodama, T.; Morio, T.; Geha, R.S.; Kitamura, D.; Kurosaki, T.; Ellmeier, W.; Takayanagi, H.
    Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals (2008), Cell, 132, 794-806.
    View publication on PubMed
Search for more literature for 2.7.10.2

Application

Application Comment Organism
medicine Btk is a potential therapeutic target for bone diseases Mus musculus
medicine Tec kinase is a potential therapeutic target for bone diseases Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
the retroviral vector pMX-Tec-IRES-GFP is constructed Mus musculus
the retroviral vectors pMX-Btk-IRES-GFP, pMX-Btk(R28C)-IRES-GFP and pMX-Btk(R525Q)-IRES-GFP are constructed Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Mus musculus
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P24604
-
-
Mus musculus P35991
-
-

Source Tissue

Source Tissue Comment Organism Textmining
osteoclast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
 Mus musculus ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Btk
-
 Mus musculus
Tec
-
 Mus musculus