Application | Comment | Organism |
---|---|---|
medicine | SYK is a good target for therapeutic intervention in allergic diseases such as asthma, roles in the development of cancer are reported | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-1,3-thiazol-4-yl)methanol | - |
Homo sapiens | |
(2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-1,3-thiazol-5-yl)methanol | - |
Homo sapiens | |
2-(2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-5-yl)ethanol | - |
Homo sapiens | |
2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-N-[(1R)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
2-[4-methyl-2-(2-[[3-methyl-5-(trifluoromethyl)phenyl]amino]pyrimidin-4-yl)-1,3-thiazol-5-yl]ethanol | - |
Homo sapiens | |
3-([4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]pyrimidin-2-yl]amino)-5-(trifluoromethyl)phenol | - |
Homo sapiens | |
3-[3-[[4-(1,3-thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenoxy]propan-1-ol | - |
Homo sapiens | |
3-[[4-(1,3-thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenol | - |
Homo sapiens | |
4-methyl-N-(3-methylphenyl)-6-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(3,5-dimethoxyphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(3,5-dimethylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(3,5-dimethylphenyl)-4-(4-methyl-1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(3,5-dimethylphenyl)-4-(5-methyl-1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(3-methylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-(3-phenoxyphenyl)-4-(thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-(5-methyl-1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
N-[3-methyl-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
[2-(2-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]pyrimidin-4-yl)-1,3-thiazol-4-yl]methanol | - |
Homo sapiens | |
[2-(2-[[3-methyl-5-(trifluoromethyl)phenyl]amino]pyrimidin-4-yl)-1,3-thiazol-4-yl]methanol | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Spleen tyrosine kinase | - |
Homo sapiens |
Syk | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000004 | - |
(2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-1,3-thiazol-5-yl)methanol | - |
Homo sapiens | |
0.000008 | - |
N-(3,5-dimethylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000009 | - |
2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
0.00001 | - |
(2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-1,3-thiazol-4-yl)methanol | - |
Homo sapiens | |
0.00001 | - |
[2-(2-[[3-methyl-5-(trifluoromethyl)phenyl]amino]pyrimidin-4-yl)-1,3-thiazol-4-yl]methanol | - |
Homo sapiens | |
0.000014 | - |
N-(3,5-dimethoxyphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000022 | - |
2-[4-methyl-2-(2-[[3-methyl-5-(trifluoromethyl)phenyl]amino]pyrimidin-4-yl)-1,3-thiazol-5-yl]ethanol | - |
Homo sapiens | |
0.000023 | - |
N-(3,5-dimethylphenyl)-4-(5-methyl-1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000023 | - |
N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-(5-methyl-1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000026 | - |
3-[3-[[4-(1,3-thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenoxy]propan-1-ol | - |
Homo sapiens | |
0.000028 | - |
N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000032 | - |
2-(2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-4-methyl-1,3-thiazol-5-yl)ethanol | - |
Homo sapiens | |
0.000033 | - |
[2-(2-[[3-methoxy-5-(trifluoromethyl)phenyl]amino]pyrimidin-4-yl)-1,3-thiazol-4-yl]methanol | - |
Homo sapiens | |
0.000044 | - |
3-[[4-(1,3-thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenol | - |
Homo sapiens | |
0.00005 | - |
3-([4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]pyrimidin-2-yl]amino)-5-(trifluoromethyl)phenol | - |
Homo sapiens | |
0.000056 | - |
N-(3,5-dimethylphenyl)-4-(4-methyl-1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.000082 | - |
N-(3-methylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.00011 | - |
N-[3-methyl-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.00021 | - |
2-[2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl]-N-[(1R)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | - |
Homo sapiens | |
0.00063 | - |
N-(3-phenoxyphenyl)-4-(thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens | |
0.001817 | - |
4-methyl-N-(3-methylphenyl)-6-(1,3-thiazol-2-yl)pyrimidin-2-amine | - |
Homo sapiens |