Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.2 extracted from

  • Tanos, B.; Pendergast, A.M.
    Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor (2006), J. Biol. Chem., 281, 32714-32723.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
epidermal growth factor receptor the Abl nonreceptor tyrosine kinase is activated by ligand-stimulated EGFR Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of EGFR and Abl in COS-7 cell surface, expression in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K290M a kinase-inactive Abl mutant Homo sapiens
additional information Abl-PP harbors mutations in prolines 242 and 249 in theSH2kinase linker domain, which are mutated to glutamic acid, rendering Abl in a constitutively active state Homo sapiens
P131L a SH3-domain mutant with increased activity compared to wild-type Abl Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + epidermal growth factor receptor Homo sapiens the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + epidermal growth factor receptor the activated Abl tyrosine kinase negaively regulates endocytosis of the epidermal growth factor, e.g. in NR6 cells, overview, Abl allows the ligand-activated EGFR to escape Cbl-dependent down-regulation by inhibiting the accumulation of Cbl at the plasma membrane in response to epidermal growth factor stimulation and disrupting the formation of the EGFR-Cbl complex without affecting Cbl protein stability Homo sapiens ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
-
?
ATP + epidermal growth factor receptor activated Abl phosphorylates the EGFR primarily on Tyr1173, no activity with the Tyr1173 mutant substrate Homo sapiens ADP + phospho-L-tyrosinyl-epidermal growth factor receptor
-
?

Synonyms

Synonyms Comment Organism
Abl
-
Homo sapiens
Abl nonreceptor tyrosine kinase
-
Homo sapiens
Abl tyrosine kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens