Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | deoxygenation of SS cells increases Syk and Lyn PTK activities, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine | i.e. pp2, inhibits Src family members like Lyn, no inhibition of Syk | Homo sapiens | |
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine | i.e. pp1, inhibits Src family members like Lyn, no inhibition of Syk | Homo sapiens | |
methyl 2,5-dihydroxycinnamate | i.e. DHC, inhibition of Syk and Lyn | Homo sapiens | |
additional information | effects of inhibitors in vivo in SS cells on K-Cl cotransport, overview | Homo sapiens | |
staurosporine | i.e. ST, inhibition of Syk and Lyn, IC50 for Syk is 0.008 mM | Homo sapiens | |
T47 | 57% inhibition of Syk at 0.1 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
erythrocyte | - |
Homo sapiens | - |
sickle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter | Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Lyn | - |
Homo sapiens |
More | Syk belongs to the Syk family of protein tyrosine kinases, Src and Lyn belong to the Src family of protein tyrosine kinases | Homo sapiens |
non-receptor PTK | - |
Homo sapiens |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Src | - |
Homo sapiens |
Syk | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.008 | - |
i.e. ST, inhibition of Syk and Lyn, IC50 for Syk is 0.008 mM | Homo sapiens | staurosporine |