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Literature summary for 2.7.10.2 extracted from

  • Laurent, C.E.; Delfino, F.J.; Cheng, H.Y.; Smithgall, T.E.
    The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly (2004), Mol. Cell. Biol., 24, 9351-9358.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of untagged or GFP-fusion wild-type and L145P mutant c-Fes tyrosine kinase in COS-7 cells, coexpression with a Src family kinase or activation via coiled-coil mutation L145P lead to c-Fes colocalization with microtubules in the cytoplasm of COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
L145P coiled-coil mutation activates the enzyme Homo sapiens
L145P/R483L mutant enzyme shows low c-Fes colocalization with microtubules Homo sapiens
R483L mutation reverses the c-Fes colocalization with microtubules Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm c-Fes is colocalized with the cytoskeleton and the mitotic spindle Homo sapiens 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens active c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly, c-Fes colocalization with microtubules in vivo requires the SH2 enzyme domain, implication in the differentiation of vascular, endothelial, myeloid, hematopoietic, and neuronal cells, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [tubulin]-L-tyrosine highly active with c-Fes, which also catalyzes tubulin polymerization in vitro Homo sapiens ADP + [tubulin]-L-tyrosine phosphate
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 ?
additional information active c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly, c-Fes colocalization with microtubules in vivo requires the SH2 enzyme domain, implication in the differentiation of vascular, endothelial, myeloid, hematopoietic, and neuronal cells, overview Homo sapiens ?
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 ?
additional information c-Fes interacts with soluble unpolymerized tubulin via its N-terminal Fes/CIP4 homology FCH domain Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
c-Fes protein-tyrosine kinase
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 Homo sapiens
c-Fes tyrosine kinase
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 Homo sapiens