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Literature summary for 2.7.10.2 extracted from

  • Browe, D.M.; Baumgarten, C.M.
    Stretch of beta 1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes (2003), J. Gen. Physiol., 122, 689-702.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
additional information Src is activated by mechanical stretch of beta1 integrin, cell swelling and integrin clustering Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine i.e. PP2, inhibits Src Oryctolagus cuniculus
genistein
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 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus Src activates an outwardly rectifying chloride current in myocytes being involved in osmotic swelling, enzyme inhibition also inhibits stretch-activated Cl- current, mechanism, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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 New Zealand white rabbits
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Source Tissue

Source Tissue Comment Organism Textmining
myocyte left ventricular Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Src activates an outwardly rectifying chloride current in myocytes being involved in osmotic swelling, enzyme inhibition also inhibits stretch-activated Cl- current, mechanism, overview Oryctolagus cuniculus ?
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 ?

Synonyms

Synonyms Comment Organism
Protein tyrosine kinase
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 Oryctolagus cuniculus
PTK
-
 Oryctolagus cuniculus
Src
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 Oryctolagus cuniculus