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Literature summary for 2.7.10.2 extracted from
- Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells (2003), J. Biol. Chem., 278, 6209-6221.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression of Syk kinase in MDA-MB-231 cells suppresses cell motility and inhibits the activation of phosphatidylinositol 3'-kinase, antisense expression of Syk kinase in MCF-7 cells or expression of wild-type Syk kinase in MDA-MB-231 cells increases cell motility and activity of phosphatidylinositol 3'-kinase | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| piceatannol | Syk kinase inhibitor | Homo sapiens |  |
| Wortmannin | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | Syk kinase is involved in cell motility and activation of phosphatidylinositol 3'-kinase, Syk kinase inhibits the tyrosine phosphorylation of IkappaBalpha and thus inhibits activation of NFkappaB via interaction of IkappaBalpha and phosphatidylinositol 3'-kinase, pathway regulation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | autophosphorylation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| hematopoietic cell | - |
Homo sapiens | - |
| MCF-7 cell | breast cancer cell line | Homo sapiens | - |
| additional information | no expression of Syk in MDA-MB-231 breast cancer cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Syk kinase is involved in cell motility and activation of phosphatidylinositol 3'-kinase, Syk kinase inhibits the tyrosine phosphorylation of IkappaBalpha and thus inhibits activation of NFkappaB via interaction of IkappaBalpha and phosphatidylinositol 3'-kinase, pathway regulation, overview | Homo sapiens | ? | - |
? | |
| additional information | Syk kinase performs autophosphorylation | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | Syk is a member of the tyrosine kinase family | Homo sapiens |
| protein-tyrosine kinase | - |
Homo sapiens |
| Syk | - |
Homo sapiens |
| Syk kinase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
in vivo assay at | Homo sapiens |
| 8 | - |
in vitro assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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