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Literature summary for 2.7.10.2 extracted from

  • Sangrar, W.; Gao, Y.; Bates, B.; Zirngibl, R.; Greer, P.A.
    Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival (2004), Exp. Hematol., 32, 935-945.
    View publication on PubMed
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
erythropoietin activates Fps/Fes tyrosine kinase Mus musculus
stem cell factor SCF activates Fps/Fes tyrosine kinase Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information a gain-of-function mutant fps/fes transgene, i.e. fpsMF, encoding an activated Fps/Fes variant, i.e. MFps, is constructed, tissue-specific expression in mice, mutant mice show reduced peripheral erythrocytes and accumulation of immature erythroid precursors displaying increased survival, activation of the mutant enzyme by erythropoietin and stem cell factor leads to increased STAT5A/B activation and reduced ERK1/2 phosphorylation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte peripheral, in bone marrow and spleen, Fps/Fes tyrosine kinase expression in early erythroid progenitors/blasts and in mature red cells Mus musculus
-
myeloid cell line
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Fps/Fes tyrosine kinase is involved in regulation of erythropoiesis and of myeloid differentiation and survival Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Fps/Fes tyrosine kinase
-
 Mus musculus