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Literature summary for 2.7.10.2 extracted from

  • Hollosy, F.; Keri, G.
    Plant-derived protein tyrosine kinase inhibitors as anticancer agents (2004), Curr. Med. Chem. Anticancer Agents, 4, 173-197.
    View publication on PubMed

Application

Application Comment Organism
drug development non-receptor PTKs are targets for design by computational chemistry of therapeutic agents based on plant-derived inhibitors from ethnopharmaceutical knowledge, high-throughput screening, tyrosine kinase inhibitors can target the ATP or the substrate binding sites, respectively, strategies, detailed overview Homo sapiens
pharmacology non-receptor PTKs are targets for inhibitors as anticancer agents Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-azaanthraquinones
-
Homo sapiens
1-methyl-emodin inhibition of p56lck and c-Src Homo sapiens
2-chloro-omega-hydroxy-emodin inhibition of p56lck and c-Src Homo sapiens
8-methyl-emodin inhibition of p56lck and c-Src Homo sapiens
acacetin inhibition of p56lck Homo sapiens
apigenin inhibition of p56lck Homo sapiens
catenarin i.e. 4-hydroxy-emodin, inhibition of p56lck and c-Src Homo sapiens
chrysin inhibition of p56lck Homo sapiens
damnacanthal an anthraquinone, strong and selective inhibition of p56lck Homo sapiens
datiscetin inhibition of p56lck Homo sapiens
emodic acid inhibition of p56lck and c-Src Homo sapiens
emodin inhibition of p56lck and c-Src Homo sapiens
emodin derivatives synthetic analogues, inhibition of p56lck and Src, overview Homo sapiens
endocrocin inhibition of p56lck and c-Src Homo sapiens
fisetin inhibition of p56lck Homo sapiens
flavone derivatives inhibition of p56lck, overview Homo sapiens
galangin inhibition of p56lck Homo sapiens
genkwanin inhibition of p56lck Homo sapiens
kaempferide inhibition of p56lck Homo sapiens
kaempferol inhibition of p56lck Homo sapiens
kaempferol-3-O-arabinoside slight inhibition of p56lck Homo sapiens
kaempferol-3-O-rhamnoside slight inhibition of p56lck Homo sapiens
luteolin inhibition of p56lck Homo sapiens
additional information analysis of inhibitory potential and cytotoxic effects of a large number of plant-derived secondary metabolites on PTKs and human tumor cell lines, respectively, overview Homo sapiens
morin inhibition of p56lck Homo sapiens
myricetin inhibition of p56lck Homo sapiens
nevadensin inhibition of p56lck Homo sapiens
paeciloquinone A inhibition of p56lck and c-Src Homo sapiens
Paeciloquinone B inhibition of p56lck and c-Src Homo sapiens
paeciloquinone C inhibition of p56lck and c-Src Homo sapiens
paeciloquinone D inhibition of p56lck and c-Src Homo sapiens
piceatannol inhibition of p56lck Homo sapiens
purpurin inhibition of p56lck and c-Src Homo sapiens
quercetin inhibition of p56lck Homo sapiens
resokaempferol inhibition of p56lck Homo sapiens
resveratrol inhibition of p56lck Homo sapiens
stilbene derivatives inhibition of p56lck, overview Homo sapiens
syringetin inhibition of p56lck Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
additional information cytoplasmic PTKs are cytoplasmic, nuclear, or anchored to the inner leaflet of the plasma membrane Homo sapiens
-
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Homo sapiens
-
thymocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [peptide]-L-tyrosine
-
Homo sapiens ADP + a [peptide]-L-tyrosine phosphate
-
?
ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
AL
-
Homo sapiens
cytoplasmic protein tyrosine kinase
-
Homo sapiens
Fgr
-
Homo sapiens
FPS
-
Homo sapiens
Lck
-
Homo sapiens
More non-receptor PTKs are grouped into several families and subfamilies Homo sapiens
non-receptor protein tyrosine kinase
-
Homo sapiens
p56lck
-
Homo sapiens
Protein tyrosine kinase
-
Homo sapiens
PTK
-
Homo sapiens
Src
-
Homo sapiens
Yes
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens