Application | Comment | Organism |
---|---|---|
drug development | non-receptor PTKs are targets for design by computational chemistry of therapeutic agents based on plant-derived inhibitors from ethnopharmaceutical knowledge, high-throughput screening, tyrosine kinase inhibitors can target the ATP or the substrate binding sites, respectively, strategies, detailed overview | Homo sapiens |
pharmacology | non-receptor PTKs are targets for inhibitors as anticancer agents | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-azaanthraquinones | - |
Homo sapiens | |
1-methyl-emodin | inhibition of p56lck and c-Src | Homo sapiens | |
2-chloro-omega-hydroxy-emodin | inhibition of p56lck and c-Src | Homo sapiens | |
8-methyl-emodin | inhibition of p56lck and c-Src | Homo sapiens | |
acacetin | inhibition of p56lck | Homo sapiens | |
apigenin | inhibition of p56lck | Homo sapiens | |
catenarin | i.e. 4-hydroxy-emodin, inhibition of p56lck and c-Src | Homo sapiens | |
chrysin | inhibition of p56lck | Homo sapiens | |
damnacanthal | an anthraquinone, strong and selective inhibition of p56lck | Homo sapiens | |
datiscetin | inhibition of p56lck | Homo sapiens | |
emodic acid | inhibition of p56lck and c-Src | Homo sapiens | |
emodin | inhibition of p56lck and c-Src | Homo sapiens | |
emodin derivatives | synthetic analogues, inhibition of p56lck and Src, overview | Homo sapiens | |
endocrocin | inhibition of p56lck and c-Src | Homo sapiens | |
fisetin | inhibition of p56lck | Homo sapiens | |
flavone derivatives | inhibition of p56lck, overview | Homo sapiens | |
galangin | inhibition of p56lck | Homo sapiens | |
genkwanin | inhibition of p56lck | Homo sapiens | |
kaempferide | inhibition of p56lck | Homo sapiens | |
kaempferol | inhibition of p56lck | Homo sapiens | |
kaempferol-3-O-arabinoside | slight inhibition of p56lck | Homo sapiens | |
kaempferol-3-O-rhamnoside | slight inhibition of p56lck | Homo sapiens | |
luteolin | inhibition of p56lck | Homo sapiens | |
additional information | analysis of inhibitory potential and cytotoxic effects of a large number of plant-derived secondary metabolites on PTKs and human tumor cell lines, respectively, overview | Homo sapiens | |
morin | inhibition of p56lck | Homo sapiens | |
myricetin | inhibition of p56lck | Homo sapiens | |
nevadensin | inhibition of p56lck | Homo sapiens | |
paeciloquinone A | inhibition of p56lck and c-Src | Homo sapiens | |
Paeciloquinone B | inhibition of p56lck and c-Src | Homo sapiens | |
paeciloquinone C | inhibition of p56lck and c-Src | Homo sapiens | |
paeciloquinone D | inhibition of p56lck and c-Src | Homo sapiens | |
piceatannol | inhibition of p56lck | Homo sapiens | |
purpurin | inhibition of p56lck and c-Src | Homo sapiens | |
quercetin | inhibition of p56lck | Homo sapiens | |
resokaempferol | inhibition of p56lck | Homo sapiens | |
resveratrol | inhibition of p56lck | Homo sapiens | |
stilbene derivatives | inhibition of p56lck, overview | Homo sapiens | |
syringetin | inhibition of p56lck | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
additional information | cytoplasmic PTKs are cytoplasmic, nuclear, or anchored to the inner leaflet of the plasma membrane | Homo sapiens | - |
- |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Homo sapiens | - |
thymocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [peptide]-L-tyrosine | - |
Homo sapiens | ADP + a [peptide]-L-tyrosine phosphate | - |
? | |
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AL | - |
Homo sapiens |
cytoplasmic protein tyrosine kinase | - |
Homo sapiens |
Fgr | - |
Homo sapiens |
FPS | - |
Homo sapiens |
Lck | - |
Homo sapiens |
More | non-receptor PTKs are grouped into several families and subfamilies | Homo sapiens |
non-receptor protein tyrosine kinase | - |
Homo sapiens |
p56lck | - |
Homo sapiens |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Src | - |
Homo sapiens |
Yes | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |