Application | Comment | Organism |
---|---|---|
drug development | PTKS are key targets for anticancer drug discovery | Homo sapiens |
pharmacology | PTKS are key targets for anticancer drug discovery | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | essential, 2 Mg2+ are required, one Mg2+ binds to ATP as MgATP-, the other Mg2+ acts as an essential activator on the enzyme, whose binding is pH-sensitive between pH 6.0 and pH 7.0, M2 binding involves Glu236 and Asp332, binding structure, overview | Homo sapiens | |
additional information | the ability of metal cations to interact with Csk correlates with a combination of ionic radius and the coordination number | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
additional information | Homo sapiens | PTKs are involved in cell signalling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | catalytic mechanism | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
ATP + poly(Glu4-Tyr) | artificial substrate | Homo sapiens | ADP + poly(Glu4-Tyr)-L-tyrosine phosphate | - |
? | |
ATP + [kdSrc kinase]-L-tyrosine | i.e. kinase-defective chicken Src mutant K295M | Homo sapiens | ADP + [kdSrc kinase]-L-tyrosine phosphate | - |
? | |
additional information | PTKs are involved in cell signalling | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C-terminal Src kinase | - |
Homo sapiens |
Csk | - |
Homo sapiens |
More | Csk belongs to the Src kinase family | Homo sapiens |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | as MgATP- | Homo sapiens |