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Literature summary for 2.7.10.2 extracted from

  • Nam, N.H.; Lee, S.; Ye, G.; Sun, G.; Parang, K.
    ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases (2004), Bioorg. Med. Chem., 12, 5753-5766.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AcpYEEI ATP-phosphopeptide conjugate Homo sapiens
ATP-1,13-Trioxa-SA-phospho-Tyr-g-p-azido-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-1,13-Trioxa-Suc-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-1,8-Diam-Suc-1,8-Diam-Suc-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-11-Aund-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-6-Ahex-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-8-Aoct-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-beta-Ala-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
ATP-gamma-S
-
Homo sapiens
additional information synthesis, inhibitory potency, and mechanism of ATP-SH2-domain-derived phosphopeptide conjugates with short or long linkers binding at the ATP-binding site, structure-activity-relationship, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P12931
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + poly(Glu4-Tyr)
-
Homo sapiens ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
Lck
-
Homo sapiens
Protein tyrosine kinase
-
Homo sapiens
PTK
-
Homo sapiens
Src
-
Homo sapiens
Src tyrosine kinase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP structure-activity-relationship, overview Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0017
-
ATP-1,13-Trioxa-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0026
-
ATP-1,13-Trioxa-SA-phospho-Tyr-g-p-azido-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0101
-
ATP-beta-Ala-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0115
-
ATP-6-Ahex-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0141
-
ATP-8-Aoct-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0158
-
ATP-11-Aund-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0161
-
ATP-1,8-Diam-Suc-1,8-Diam-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
0.0253
-
ATP-1,13-Trioxa-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.03
-
ATP-1,13-Trioxa-SA-phospho-Tyr-g-p-azido-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.0355
-
ATP-8-Aoct-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.0426
-
ATP-1,8-Diam-Suc-1,8-Diam-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.0455
-
ATP-6-Ahex-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.0472
-
ATP-11-Aund-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.0571
-
ATP-gamma-S 30°C, Src Homo sapiens
0.1078
-
ATP-beta-Ala-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
0.1414
-
AcpYEEI 30°C, Src Homo sapiens