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Literature summary for 2.7.10.2 extracted from

  • Colamonici, O.; Yan, H.; Domanski, P.; Handa, R.; Smalley, D.; Mullersman, J.; Witte, M.; Krishnan, K.; Krolewski, J.
    Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase (1994), Mol. Cell. Biol., 14, 8133-8142.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein tyrosine Homo sapiens p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R ADP + protein tyrosine phosphate
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?
additional information Homo sapiens p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R. Tyk2 protein functions as part of a receptor complex to initiate intracellular signaling in response to type I interferons ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P29597
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tyrosine p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R Homo sapiens ADP + protein tyrosine phosphate
-
?
additional information p135tyk2 tyrosine kinase directly binds and tyrosine phosphorylates alpha subunit of the type I IFN receptor, IFN-R. Tyk2 protein functions as part of a receptor complex to initiate intracellular signaling in response to type I interferons Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
non-receptor tyrosine-protein kinase TYK2
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Homo sapiens
p135tyk2 tyrosine kinase
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Homo sapiens