Literature summary for 2.7.10.2 extracted from

Pisabarro, M.T.; Serrano, L.; Wilmanns, M.
Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions (1998), J. Mol. Biol., 281, 513-521.

Search for more literature for 2.7.10.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions. High-affinity SH3 ligands can compete for these interactions and specifically activate the Abl kinase	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of the Abl-SH3 domain in complex with the high-affinity peptide ligand p41 at 1.6 A resolution	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00519	-	-

Synonyms

Synonyms	Comment	Organism
Abl kinase	-	Homo sapiens
proto-oncogene tyrosine-protein kinase ABL1	-	Homo sapiens

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Release 2023.1 (January 2023)