Cloned (Comment) | Organism |
---|---|
expression in U2OS cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q08345 | DDR1 | - |
Synonyms | Comment | Organism |
---|---|---|
DDR1 | - |
Homo sapiens |
discoidin domain receptor tyrosine kinase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Notch1 protein is an interacting partner of receptor tyrosine kinase DDR1. Upon ligand-mediated DDR1 kinase activation, Notch1 is activated, binds to DDR1, and activates canonical Notch1 targets, including Hes1 and Hey2. DDR1 ligand collagen I treatment significantly increases the active form of Notch1 receptor in the nuclear fraction, whereas DDR1 knockdown cells show little or no increase of the active form of Notch1 in the nuclear fraction. DDR1 activation suppresses genotoxic-mediated cell death. The DDR1 knockdown cancer cells show the reduced transformed phenotypes in vitro and in vivo xenograft studies | Homo sapiens |