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Literature summary for 2.7.10.1 extracted from

  • Kim, H.; Hwang, S.; Aaronson, S.; Mandinova, A.; Lee, S.
    DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation (2011), J. Biol. Chem., 286, 17672-17681.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in U2OS cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q08345 DDR1
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Synonyms

Synonyms Comment Organism
DDR1
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Homo sapiens
discoidin domain receptor tyrosine kinase 1
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Homo sapiens

General Information

General Information Comment Organism
physiological function Notch1 protein is an interacting partner of receptor tyrosine kinase DDR1. Upon ligand-mediated DDR1 kinase activation, Notch1 is activated, binds to DDR1, and activates canonical Notch1 targets, including Hes1 and Hey2. DDR1 ligand collagen I treatment significantly increases the active form of Notch1 receptor in the nuclear fraction, whereas DDR1 knockdown cells show little or no increase of the active form of Notch1 in the nuclear fraction. DDR1 activation suppresses genotoxic-mediated cell death. The DDR1 knockdown cancer cells show the reduced transformed phenotypes in vitro and in vivo xenograft studies Homo sapiens