Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N4-(2-fluoro-4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1; shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1 | Homo sapiens | |
N4-(4-chloro-2-fluorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1; shows potent inhibition of VEGFR-2 over EGFR, platelet-derived growth factor receptor-beta and VEGFR-1 | Homo sapiens | |
N4-(4-chloro-2-fluorophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | potent, multiple receptor tyrosine kinase inhibitor; potent, multiple receptor tyrosine kinase inhibitor | Homo sapiens | |
N4-(4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | potent, multiple receptor tyrosine kinase inhibitor; potent, multiple receptor tyrosine kinase inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17948 | VEGFR-1 | - |
Homo sapiens | P35968 | VEGFR-2 | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(2-fluoro-4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.00048 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(4-chloro-2-fluorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0152 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.016 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(4-chloro-2-fluorophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0298 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(4-chloro-2-fluorophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.0567 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.185 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(2-fluoro-4-chlorophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | |
0.2 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N4-(4-chloro-2-fluorophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine |