Literature summary for 2.7.10.1 extracted from

Khanwelkar, R.; Chen, G.; Wang, H.; Yu, C.; Huang, C.; Lee, O.; Chen, C.; Hwang, C.; Ko, C.; Chou, N.; Lin, M.; Wang, L.; Chen, Y.; Hseu, T.; Chang, C.; Hsu, H.; Lin, H.; Shih, Y.; Chou, S.; Tseng, H.; Liu, C.; Tu, C.; Hu, T.; Tsai, Y.; Chern, J.
Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors (2010), Bioorg. Med. Chem., 18, 4674-4686.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(Z)-5-[6-[3-(4-methoxyphenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl]-4-methyl-1H-pyrrole-3-carboxylic acid	potent inhibitor against tyrosine kinases, including VEGFR and PDGFR families, as well as Aurora kinases	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16234	PDGFRalpha	-

Synonyms

Synonyms	Comment	Organism
platelet-derived growth factor receptor alpha	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00000098	-	pH 7.5, 22°C	Homo sapiens	(Z)-5-[6-[3-(4-methoxyphenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl]-4-methyl-1H-pyrrole-3-carboxylic acid

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Release 2023.1 (January 2023)