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Literature summary for 2.7.10.1 extracted from

  • Klatt, A.; Zhang, Z.; Kalantari, P.; Hankey, P.A.; Gilmour, D.S.; Henderson, A.J.
    The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity (2008), J. Immunol., 180, 1670-1677.
    View publication on PubMed
Search for more literature for 2.7.10.1

Application

Application Comment Organism
medicine RON represses HIV transcription at multiple transcriptional check points including initiation, elongation and chromatin organization. RON expression decreases basal levels of NF-kappaB and RNA polymerase II binding to the HIV provirus long terminal repeat but does not prevent the induction of these complexes following treatment with cytokines. RON decreases efficient transcription elongation because reduced RNA polymerase II is associated with HIV-1 genomic sequences downstream of the transcriptional start site. There is a correlation between RON expression and increased binding of factors that negatively regulate transcription elongation, NELF, Spt5, and Pcf11. The ability of RON to inhibit HIV-1 transcription is associated with nucleosome remodeling Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
Ron mutants expressed in U-937 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutating either Y1353, Y1360, or the kinase domain ablates the ability of Ron to repress HIV-1 transcription Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
trichostatin A the ability of RON to inhibit HIV-1 transcription is sensitive to a histone deacetylase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
U-937 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
receptor tyrosine kinase RON
-
 Homo sapiens
Ron
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 Homo sapiens