Literature summary for 2.7.10.1 extracted from

Brantley-Sieders, D.M.; Zhuang, G.; Hicks, D.; Fang, W.B.; Hwang, Y.; Cates, J.M.; Coffman, K.; Jackson, D.; Bruckheimer, E.; Muraoka-Cook, R.S.; Chen, J.
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling (2008), J. Clin. Invest., 118, 64-78.

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Application

Application	Comment	Organism
medicine	EphA2 cooperates with ErbB2 to promote tumor progression and may provide a novel therapeutic target for ErbB2-dependent tumors. EphA2 function in tumor progression appears to depend on oncogene context, an important consideration for the application of therapies targeting EphA2	Homo sapiens
medicine	EphA2 cooperates with ErbB2 to promote tumor progression and may provide a novel therapeutic target for ErbB2-dependent tumors. EphA2 function in tumor progression appears to depend on oncogene context, an important consideration for the application of therapies targeting EphA2	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	EphA2 deficiency impairs tumor progression in MMTV-Neu mice, but not MMTV-PyV-mT, transgenic models of mammary epithelial adenocarcinoma	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29317	-	-
Mus musculus	Q03145	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	EphA2 forms a complex with ErbB2, resulting in enhanced activation of Ras-MAPK signaling and RhoA GTPase	Homo sapiens	-
breast cancer cell	EphA2 forms a complex with ErbB2, resulting in enhanced activation of Ras-MAPK signaling and RhoA GTPase	Mus musculus	-
MCF-10A cell	elevated EphA2 expression augments growth and invasiveness of MCF10A cells overexpressing ErbB2	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
EphA2	-	Homo sapiens
EphA2	-	Mus musculus
receptor tyrosine kinase EphA2	-	Homo sapiens
receptor tyrosine kinase EphA2	-	Mus musculus

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Release 2023.1 (January 2023)