Application | Comment | Organism |
---|---|---|
medicine | in wound-healing, Ror2 plays critical roles in Wnt5a-induced cell migration by regulating formation of lamellipodia and reorientation of microtubule-organizing center. Wnt5a/Ror2 activates c-Jun N-terminal kinase JNK, through a process involving filamin A and PKCsigma, to regulate polarized cell migration | Mus musculus |
medicine | in wound-healing, Ror2 plays critical roles in Wnt5a-induced cell migration by regulating formation of lamellipodia and reorientation of microtubule-organizing center. Wnt5a/Ror2 activates c-Jun N-terminal kinase JNK, through a process involving filamin A and PKCsigma, to regulate polarized cell migration | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | differences in Wnt5a-induced wound closure and microtubule-organizing center reorientation are not detectable in immortalized mouse embryonic fibroblasts from wild-type and Ror2-/- embryos | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | suppressed expression of Ror2, which results in impaired microtubule-organizing center reorientation following Wnt5a stimulation | Homo sapiens | |
siRNA | knocks down Ror2 expression, results in a drastic inhibition of Wnt5a CM- or purified Wnt5a-induced wound closure and no lamellipodia formation following Wnt5a stimulation. Wnt5a-induced microtubule-organizing center reorientation is also impaired in Ror2-depleted cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01974 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
NIH-3T3 cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
receptor tyrosine kinase Ror2 | - |
Mus musculus |
receptor tyrosine kinase Ror2 | - |
Homo sapiens |