Literature summary for 2.7.10.1 extracted from

Schulte, J.H.; Kuhfittig-Kulle, S.; Klein-Hitpass, L.; Schramm, A.; Biard, D.S.; Pfeiffer, P.; Eggert, A.
Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells (2008), DNA Repair, 7, 1757-1764.

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Activating Compound

Activating Compound	Comment	Organism	Structure
brain-derived neurotrophic factor	activates TrkB	Homo sapiens
additional information	sustained Ras activation in response to TrkA activation mediates differentiation, whereas transient activation results in proliferation	Rattus norvegicus
nerve growth factor	activates TrkA, which leads to differentiation of neurons and neurobalstoma cells, whereas it induces proliferation of fibroblasts and apoptosis of medulloblastoma cells	Homo sapiens
neurotrophin 3	activates TrkC	Homo sapiens
neurotrophin 4	activates TrkB	Homo sapiens

Application

Application	Comment	Organism
medicine	TrkA and TrkB are the major players in neuroblastoma biology. High expression of TrkA is associated with favorable prognosis, but also with a lack of structural chromosomal changes, whereas TrkB is mainly expressed on neuroblastoma demonstrating high genomic instability. TrkB is associated with a favorable biology and good prognosis in medullary thyroid carcinoma	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
TrkA or TrkB stably expressed in SH-SY5Y cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	TrkA mutants defective in association sites for intracellular effector molecules in normal neuronal cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16288	-	-
Rattus norvegicus	P35739	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
medulloblastoma cell	TrkC	Homo sapiens	-
additional information	Trks appear to have a high capacity for ligand-independent activation, presumably via spontaneous interactions. High levels of Trk expression elicit autophosphorylation in the absence of neurotrophins	Homo sapiens	-
neuroblastoma cell	high expression of TrkA in neuroblastomas with favorable biological features and is highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. TrkC is highly expressed in favorable neuroblastomas	Homo sapiens	-
PC-12 cell	-	Rattus norvegicus	-
SH-SY5Y cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TrkA	-	Rattus norvegicus
TrkA	-	Homo sapiens
trkB	-	Homo sapiens
TrkC	-	Homo sapiens

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Release 2023.1 (January 2023)