Activating Compound | Comment | Organism | Structure |
---|---|---|---|
brain-derived neurotrophic factor | activates TrkB | Homo sapiens | |
additional information | sustained Ras activation in response to TrkA activation mediates differentiation, whereas transient activation results in proliferation | Rattus norvegicus | |
nerve growth factor | activates TrkA, which leads to differentiation of neurons and neurobalstoma cells, whereas it induces proliferation of fibroblasts and apoptosis of medulloblastoma cells | Homo sapiens | |
neurotrophin 3 | activates TrkC | Homo sapiens | |
neurotrophin 4 | activates TrkB | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | TrkA and TrkB are the major players in neuroblastoma biology. High expression of TrkA is associated with favorable prognosis, but also with a lack of structural chromosomal changes, whereas TrkB is mainly expressed on neuroblastoma demonstrating high genomic instability. TrkB is associated with a favorable biology and good prognosis in medullary thyroid carcinoma | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
TrkA or TrkB stably expressed in SH-SY5Y cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | TrkA mutants defective in association sites for intracellular effector molecules in normal neuronal cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16288 | - |
- |
Rattus norvegicus | P35739 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
medulloblastoma cell | TrkC | Homo sapiens | - |
additional information | Trks appear to have a high capacity for ligand-independent activation, presumably via spontaneous interactions. High levels of Trk expression elicit autophosphorylation in the absence of neurotrophins | Homo sapiens | - |
neuroblastoma cell | high expression of TrkA in neuroblastomas with favorable biological features and is highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. TrkC is highly expressed in favorable neuroblastomas | Homo sapiens | - |
PC-12 cell | - |
Rattus norvegicus | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
TrkA | - |
Rattus norvegicus |
TrkA | - |
Homo sapiens |
trkB | - |
Homo sapiens |
TrkC | - |
Homo sapiens |