Activating Compound | Comment | Organism | Structure |
---|---|---|---|
estrogen | induces Ret expression | Homo sapiens | |
glial-derived neutrophic factor | triggers signaling pathway activation in breast tumor cell lines in a Ret-dependent manner. 10 ng/mL glial-derived neutrophic factor alone or in combination with 100ng/mL glial-derived neutrophic factor receptor alpha1 is the optimal concentration promoting activation of downstream signaling in breast cancer cell lines | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | Ret is expressed in primary breast tumors and is functional in a panel of breast tumor cell lines, in particular, cell lines characterized for their dependence on endocrine signaling. Ret signaling stimulates anchorage-independent proliferation of breast cancer cells. Functional interaction with estrogen receptor alpha signaling in vitro strengthens the potential of Ret pathway inhibition in a combination approach with endocrine therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
Ret9-MEN2A overexpressed in NIH-3T3 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NVP-BBT594 | - |
Homo sapiens | |
siRNA | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BT-474 cell | moderate expression | Homo sapiens | - |
MCF-7 cell | high expression | Homo sapiens | - |
MDA-MB-361 cell | high expression | Homo sapiens | - |
MDA-MB-453 cell | moderate expression | Homo sapiens | - |
additional information | high expression in MDA-MB-134 cell, MDA-MB-175 cell, HCC-1419 cell and HCC-2218 cell. no expression in HCC1937 cell, HCC1954 cell, MDA-MB231 cell and MDA-MB468 cell | Homo sapiens | - |
SK-BR-3 cell | moderate expression | Homo sapiens | - |
T-47D cell | moderate expression | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Ret receptor tyrosine kinase | - |
Homo sapiens |
Ret51 | - |
Homo sapiens |
Ret9 | - |
Homo sapiens |