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Literature summary for 2.7.10.1 extracted from

  • Hong, C.C.; Lay, J.D.; Huang, J.S.; Cheng, A.L.; Tang, J.L.; Lin, M.T.; Lai, G.M.; Chuang, S.E.
    Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia (2008), Cancer Lett., 268, 314-324.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cisplatin AXL can be induced by chemotherapy drugs in acute myeloid leukemia U937 cells and this induction is dependent on the CCWGG methylation status of the AXL promoter Homo sapiens
doxorubicin AXL can be induced by chemotherapy drugs in acute myeloid leukemia U937 cells and this induction is dependent on the CCWGG methylation status of the AXL promoter Homo sapiens
Gas6 in U937 cells ectopically overexpressing AXL, addition of exogenous Gas6 induces AXL phosphorylation and activation of the Akt and ERK1/2 survival pathways. The Gas6-AXL activation pathway of drug resistance is associated with increased expression of Bcl-2 and Twist Homo sapiens
VP16 AXL can be induced by chemotherapy drugs in acute myeloid leukemia U937 cells and this induction is dependent on the CCWGG methylation status of the AXL promoter Homo sapiens

Application

Application Comment Organism
medicine AXL is overexpressed in leukemia cells isolated from acute myeloid leukemia patients who develop drug resistance after chemotherapy. Upregulation of AXL by chemotherapy may induce drug resistance in acute myeloid leukemia in the presence of Gas6 stimulation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
ligated into the pcDNA3 vector. Introduction of the AXL recombinant plasmid and shRNA expression vector into U937 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell from peripheral bloods or bone marrows Homo sapiens
-
U-937 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Axl
-
Homo sapiens
receptor tyrosine kinase
-
Homo sapiens