Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cisplatin | AXL can be induced by chemotherapy drugs in acute myeloid leukemia U937 cells and this induction is dependent on the CCWGG methylation status of the AXL promoter | Homo sapiens | |
doxorubicin | AXL can be induced by chemotherapy drugs in acute myeloid leukemia U937 cells and this induction is dependent on the CCWGG methylation status of the AXL promoter | Homo sapiens | |
Gas6 | in U937 cells ectopically overexpressing AXL, addition of exogenous Gas6 induces AXL phosphorylation and activation of the Akt and ERK1/2 survival pathways. The Gas6-AXL activation pathway of drug resistance is associated with increased expression of Bcl-2 and Twist | Homo sapiens | |
VP16 | AXL can be induced by chemotherapy drugs in acute myeloid leukemia U937 cells and this induction is dependent on the CCWGG methylation status of the AXL promoter | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | AXL is overexpressed in leukemia cells isolated from acute myeloid leukemia patients who develop drug resistance after chemotherapy. Upregulation of AXL by chemotherapy may induce drug resistance in acute myeloid leukemia in the presence of Gas6 stimulation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
ligated into the pcDNA3 vector. Introduction of the AXL recombinant plasmid and shRNA expression vector into U937 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | from peripheral bloods or bone marrows | Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Axl | - |
Homo sapiens |
receptor tyrosine kinase | - |
Homo sapiens |