Literature summary for 2.7.10.1 extracted from

Ewan, L.C.; Jopling, H.M.; Jia, H.; Mittar, S.; Bagherzadeh, A.; Howell, G.J.; Walker, J.H.; Zachary, I.C.; Ponnambalam, S.
Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells (2006), Traffic, 7, 1270-1282.

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Inhibitors

Inhibitors	Comment	Organism	Structure
SU5416	selective inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + a [protein]-L-tyrosine	Homo sapiens	-	ADP + a [protein]-L-tyrosine phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a [protein]-L-tyrosine	-	Homo sapiens	ADP + a [protein]-L-tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Flk-1	-	Homo sapiens
KDR/fetal liver kinase-1	-	Homo sapiens
vascular endothelial growth factor receptor 2	-	Homo sapiens
VEGFR2/kinase domain region	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)