Inhibitors | Comment | Organism | Structure |
---|---|---|---|
imatinib mesylate | potent inhibitor | Homo sapiens | |
phosphotyrosyl phosphatase Shp1 | Shp1 binds to c-Kit at Y570 and acts by dephosphorylating the receptor directly, or inhibits c-Kit signalling indirectly by dephosphorylating other receptor-associated protein-tyrosine kinases | Homo sapiens | |
Protein kinase C | subsequently phosphorylates c-Kit on specific serine residues leading to negative regulation of c-Kit activation | Homo sapiens | |
STI571 | commercial Gleevec/Glivec, specific inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic stem cell | - |
Homo sapiens | - |
mast cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-kit | - |
Homo sapiens |
c-Kit RTK | - |
Homo sapiens |
CD117 | - |
Homo sapiens |
stem cell factor receptor | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |