Literature summary for 2.7.10.1 extracted from

Fang, Y.; Han, S.I.; Mitchell, C.; Gupta, S.; Studer, E.; Grant, S.; Hylemon, P.B.; Dent, P.
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes (2004), Hepatology, 40, 961-971.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	deoxycholic acid and taurodeoxycholic acid enhance enzyme activity by inhibition of protein tyrosine phosphatases PTPases	Rattus norvegicus
reactive oxygen species	deoxycholic acid and taurodeoxycholic acid activate insulin receptor kinase and ERBB1 kinase and subsequent signaling pathway activation via induction of reactive oxygen species ROS production in mitochondria, ROS activation can be blocked by scavengers N-acetyl cysteine and Trolox, as well as cyclosporine A and bongkrekic acid	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	deoxycholic acid and taurodeoxycholic acid activate insulin receptor kinase and ERBB1 kinase and subsequent ERK1/2 and AKT signaling pathways activation via induction of reactive oxygen species ROS production in mitochondria, ROS activation can be blocked by scavengers N-acetyl cysteine and Trolox, as well as cyclosporine A and bongkrekic acid	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male sprague-dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary cells	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	deoxycholic acid and taurodeoxycholic acid activate insulin receptor kinase and ERBB1 kinase and subsequent ERK1/2 and AKT signaling pathways activation via induction of reactive oxygen species ROS production in mitochondria, ROS activation can be blocked by scavengers N-acetyl cysteine and Trolox, as well as cyclosporine A and bongkrekic acid	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
epidermal growth factor receptor	-	Rattus norvegicus
ERBB1	-	Rattus norvegicus
insulin receptor	-	Rattus norvegicus
receptor tyrosine kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)