Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | activates enzyme tyrosine autophosphorylation | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of insulin receptor kinase in CHO cells as GST-fusion protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cr3+ | activates insulin receptor tyrosine phosphorylation in vivo | Homo sapiens | |
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | tyrosine autophosphorylation of the insulin receptor kinase induced by insulin binding, also in vivo tyrosine autophosphorylation in recombinant CHO cells after addition of insulin, dephosphorylation by protein tyrosine phosphatase PTP1B | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + KKHTDDGYMPMSPGVA | commercial peptide substrate | Homo sapiens | ADP + KKHTDDGY-phosphate-MPMSPGVA | - |
? | |
ATP + KKSRGDYMTMQIG | commercial peptide substrate | Homo sapiens | ADP + KKSRGDY-phosphate-MTMQIG | - |
? | |
additional information | the insulin receptor tyrosine kinase performs insulin-induced autophosphorylation, regulatory dephosphorylation by protein tyrosine phosphatase PTP1B | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
insulin receptor kinase | - |
Homo sapiens |
IR kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |