Cloned (Comment) | Organism |
---|---|
- |
Streptomyces rimosus |
Protein Variants | Comment | Organism |
---|---|---|
S146A | 19% of the activity of phosphorylated wild-type, 90% of the activity of unphosphorylated wild-type, in presence of Ca2+ | Streptomyces rimosus |
S146A/S160A | 17% of the activity of phosphorylated wild-type, 85% of the activity of unphosphorylated wild-type, in presence of Ca2+ | Streptomyces rimosus |
S146A/S160A/S215A | 17% of the activity of phosphorylated wild-type, 60% of the activity of unphosphorylated wild-type, in presence of Ca2+ | Streptomyces rimosus |
S215A | 88% of the activity of phosphorylated wild-type, 67% of the activity of unphosphorylated wild-type, in presence of Ca2+ | Streptomyces rimosus |
S95A/S160A | 82% of the activity of phosphorylated wild-type, 95% of the activity of unphosphorylated wild-type, in presence of Ca2+ | Streptomyces rimosus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces rimosus | - |
- |
- |
Streptomyces rimosus ATCC 10970 | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | residue Ser146 in the activation loop of the enzyme is the key site for Ca2+-dependent phosphorylation of isoform APHVIII. The Ser146 modification leads to a 6-7-fold increase in the kanamycin kinase activity of APHVII | Streptomyces rimosus |
Synonyms | Comment | Organism |
---|---|---|
aminoglycoside phosphotransferase VIII | - |
Streptomyces rimosus |
APH | - |
Streptomyces rimosus |