Application | Comment | Organism |
---|---|---|
diagnostics | overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma and thus the enzyme has potential as a prognostic factor for overall survival in in nasopharyngeal carcinoma, and for lymph node metastasis in nasopharyngeal carcinoma | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene agk, quantitative real-time PCR expression analysis of AGK | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acylglycerol | Homo sapiens | - |
ADP + acyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q53H12 | gene agk | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
5-8F cell | - |
Homo sapiens | - |
6-10B cell | - |
Homo sapiens | - |
CNE-1 cell | - |
Homo sapiens | - |
CNE-2 cell | - |
Homo sapiens | - |
HK-1 cell | - |
Homo sapiens | - |
lymph node | - |
Homo sapiens | - |
nasopharyngeal carcinoma cell | enzyme AGK is significantly upregulated in NPC cell lines and clinical specimens as indicated by real-time PCR and Western blotting, overview | Homo sapiens | - |
nasopharyngeal epithelium | primary, healthy | Homo sapiens | - |
NP-69 cell | - |
Homo sapiens | - |
SUNE-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acylglycerol | - |
Homo sapiens | ADP + acyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AGK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | by acting as a lipid kinase, AGK catalyzes the phosphorylation of acylglycerol to generate lysophosphatidic acid , which is known to be involved in tumor progression, invasion, neovascularization, and metastasis. Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma. High expression of enzyme AGK is associated with significantly shorter overall and disease-free survival and is an independent prognostic factor for overall survival. High AGK expression is associated with lymph node metastasis and is an independent predicted factor for lymph node metastasis in nasopharyngeal carcinoma | Homo sapiens |