BRENDA - Enzyme Database show
show all sequences of 2.7.1.91

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors

Baek, D.; MacRitchie, N.; Anthony, N.; MacKay, S.; Pyne, S.; Pyne, N.; Bittman, R.; J. Med. Chem. 56, 9310-9327 (2013)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
(4-hydroxypiperidin-1-yl)(4-octylphenyl)methanone
-
Homo sapiens
2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethanol
-
Homo sapiens
4-(4-octyl-1H-1,2,3-triazol-1-yl)phenol
-
Homo sapiens
4-octyl-N-(pyridin-4-ylmethyl)benzamide
-
Homo sapiens
N-(4-hydroxyphenyl)-4-octylbenzamide
-
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
(2S)-1-(4-dodecylbenzoyl)pyrrolidine-2-carboximidamide
-
Homo sapiens
(3R)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-3-ol
;
Homo sapiens
(3S)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-3-ol
;
Homo sapiens
(4-dodecylphenyl)(4-hydroxypiperidin-1-yl)methanone
;
Homo sapiens
(4-dodecylphenyl)[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone
;
Homo sapiens
(4-dodecylphenyl)[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone
;
Homo sapiens
(S)-1-(4-dodecylbenzoyl)pyrrolidine-2-carboximidamide
-
Homo sapiens
1-(4-dodecylphenethyl)piperidin-4-amine
;
Homo sapiens
1-(4-methylphenethyl)piperidin-4-amine
-
Homo sapiens
1-(4-octylbenzyl)piperidin-4-ol
;
Homo sapiens
1-(4-octylphenethyl)piperidin-4-amine
-
Homo sapiens
1-(4-octylphenethyl)piperidin-4-ol
a selective inhibitor of isozyme SK1, structure-activity relationship profile
Homo sapiens
1-methyl-1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidinium
;
Homo sapiens
1-methyl-1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidinium
;
Homo sapiens
1-methyl-2-[2-(4-octylphenyl)ethyl]pyridinium
;
Homo sapiens
1-[2-(4-dodecylphenyl)ethyl]piperidin-4-ol
;
Homo sapiens
1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-(4-octylphenyl)ethyl]piperidin-4-one
;
Homo sapiens
1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]-1-methylpiperidinium
;
Homo sapiens
1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol
;
Homo sapiens
1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidine
;
Homo sapiens
1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidine
;
Homo sapiens
1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidine
;
Homo sapiens
1-[3-(4-octylphenyl)propyl]piperidin-4-ol
;
Homo sapiens
1-[4-(4-octylphenyl)butyl]piperidin-4-ol
;
Homo sapiens
2-(hydroxymethyl)-1-[2-[4-([4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]ethyl]piperidin-4-ol
;
Homo sapiens
2-[2-(4-octylphenyl)ethyl]pyridine
;
Homo sapiens
2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethanol
-
Homo sapiens
3-[4-(4-octylphenyl)-1H-1,2,3-triazol-1-yl]pyridine
;
Homo sapiens
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol
-
Homo sapiens
4-(4-octyl-1H-1,2,3-triazol-1-yl)phenol
-
Homo sapiens
4-azido-1-(4-methylphenethyl)piperidine
;
Homo sapiens
4-azido-1-(4-octylphenethyl)piperidine
;
Homo sapiens
4-fluoro-1-[2-(4-octylphenyl)ethyl]piperidine
;
Homo sapiens
4-methoxy-1-[2-(4-octylphenyl)ethyl]piperidine
;
Homo sapiens
4-octyl-N-(pyridin-4-ylmethyl)benzamide
-
Homo sapiens
ABC294640
;
Homo sapiens
BML-258
; 74.5% inhibition at 0.05 mM
Homo sapiens
FTY-720
;
Homo sapiens
additional information
design, synthesis, and evaluation of the potency of isoform-selective inhibitors of sphingosine kinases 1 and 2 using SK1 inhibitor RB-005 as lead compound, structure-activity relationships and molecular modeling of sphingosine kinase inhibitors, overview. No or poor inibition by 1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol, 1-(4-methylphenethyl)piperidin-4-amine, 1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]-1-methylpiperidinium, and 1-methyl-1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidinium, while potential inhibitors (4-hydroxypiperidin-1-yl)(4-octylphenyl)methanone, 4-octyl-N-(pyridin-4-ylmethyl)benzamide, N-(4-hydroxyphenyl)-4-octylbenzamide, 4-(4-octyl-1H-1,2,3-triazol-1-yl)phenol, and 2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethanol are slightly activating; design, synthesis, and evaluation of the potency of isoform-selective inhibitors of sphingosine kinases 1 and 2 using SK1 inhibitor RB-005 as lead compound, structure-activity relationships and molecular modeling of sphingosine kinase inhibitors, overview. No or poor inibition by 1-(4-methylphenethyl)piperidin-4-amine, 1-(4-octylphenethyl)piperidin-4-amine, 1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol, and 1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol, while potential inhibitors 1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol, 1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol, [(2S)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-2-yl]methanol, and (4-hydroxypiperidin-1-yl)(4-octylphenyl)methanone are slightly activating
Homo sapiens
N,N-dimethylsphingosine
;
Homo sapiens
N-(4-hydroxyphenyl)-4-octylbenzamide
-
Homo sapiens
N-cyclohexyl-N-(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)acetamide
;
Homo sapiens
N-[4-(2-hydroxyethyl)phenyl]-4-octylbenzamide
;
Homo sapiens
PF-543
;
Homo sapiens
SLR080811
;
Homo sapiens
[(2R)-1-[2-(4-dodecylphenyl)ethyl]pyrrolidin-2-yl]methanol
;
Homo sapiens
[(2R)-1-[2-(4-methylphenyl)ethyl]pyrrolidin-2-yl]methanol
;
Homo sapiens
[(2R)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-2-yl]methanol
;
Homo sapiens
[(2S)-1-[2-(4-dodecylphenyl)ethyl]pyrrolidin-2-yl]methanol
;
Homo sapiens
[(2S)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-2-yl]methanol
-
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-erythro-sphingosine
Homo sapiens
-
ADP + D-erythro-sphingosine 1-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9NRA0
sphingosine kinase isoform 2
-
Homo sapiens
Q9NYA1
sphingosine kinase isoform 1
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-erythro-sphingosine
-
738830
Homo sapiens
ADP + D-erythro-sphingosine 1-phosphate
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
ATP
;
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
(4-hydroxypiperidin-1-yl)(4-octylphenyl)methanone
-
Homo sapiens
2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethanol
-
Homo sapiens
4-(4-octyl-1H-1,2,3-triazol-1-yl)phenol
-
Homo sapiens
4-octyl-N-(pyridin-4-ylmethyl)benzamide
-
Homo sapiens
N-(4-hydroxyphenyl)-4-octylbenzamide
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
ATP
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(2S)-1-(4-dodecylbenzoyl)pyrrolidine-2-carboximidamide
-
Homo sapiens
(3R)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-3-ol
-
Homo sapiens
(3S)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-3-ol
-
Homo sapiens
(4-dodecylphenyl)(4-hydroxypiperidin-1-yl)methanone
-
Homo sapiens
(4-dodecylphenyl)[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone
-
Homo sapiens
(4-dodecylphenyl)[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methanone
-
Homo sapiens
(S)-1-(4-dodecylbenzoyl)pyrrolidine-2-carboximidamide
-
Homo sapiens
1-(4-dodecylphenethyl)piperidin-4-amine
-
Homo sapiens
1-(4-methylphenethyl)piperidin-4-amine
-
Homo sapiens
1-(4-octylbenzyl)piperidin-4-ol
-
Homo sapiens
1-(4-octylphenethyl)piperidin-4-amine
-
Homo sapiens
1-(4-octylphenethyl)piperidin-4-ol
a selective inhibitor of isozyme SK1, structure-activity relationship profile
Homo sapiens
1-methyl-1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidinium
-
Homo sapiens
1-methyl-1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidinium
-
Homo sapiens
1-methyl-2-[2-(4-octylphenyl)ethyl]pyridinium
-
Homo sapiens
1-[2-(4-dodecylphenyl)ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-(4-octylphenyl)ethyl]piperidin-4-one
-
Homo sapiens
1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]-1-methylpiperidinium
-
Homo sapiens
1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidine
-
Homo sapiens
1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidine
-
Homo sapiens
1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol
-
Homo sapiens
1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidine
-
Homo sapiens
1-[3-(4-octylphenyl)propyl]piperidin-4-ol
-
Homo sapiens
1-[4-(4-octylphenyl)butyl]piperidin-4-ol
-
Homo sapiens
2-(hydroxymethyl)-1-[2-[4-([4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]ethyl]piperidin-4-ol
-
Homo sapiens
2-[2-(4-octylphenyl)ethyl]pyridine
-
Homo sapiens
2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethanol
-
Homo sapiens
3-[4-(4-octylphenyl)-1H-1,2,3-triazol-1-yl]pyridine
-
Homo sapiens
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol
-
Homo sapiens
4-(4-octyl-1H-1,2,3-triazol-1-yl)phenol
-
Homo sapiens
4-azido-1-(4-methylphenethyl)piperidine
-
Homo sapiens
4-azido-1-(4-octylphenethyl)piperidine
-
Homo sapiens
4-fluoro-1-[2-(4-octylphenyl)ethyl]piperidine
-
Homo sapiens
4-methoxy-1-[2-(4-octylphenyl)ethyl]piperidine
-
Homo sapiens
4-octyl-N-(pyridin-4-ylmethyl)benzamide
-
Homo sapiens
ABC294640
-
Homo sapiens
BML-258
74.5% inhibition at 0.05 mM
Homo sapiens
BML-258
-
Homo sapiens
FTY-720
-
Homo sapiens
additional information
design, synthesis, and evaluation of the potency of isoform-selective inhibitors of sphingosine kinases 1 and 2 using SK1 inhibitor RB-005 as lead compound, structure-activity relationships and molecular modeling of sphingosine kinase inhibitors, overview. No or poor inibition by 1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol, 1-(4-methylphenethyl)piperidin-4-amine, 1-[2-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]-1-methylpiperidinium, and 1-methyl-1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidinium, while potential inhibitors (4-hydroxypiperidin-1-yl)(4-octylphenyl)methanone, 4-octyl-N-(pyridin-4-ylmethyl)benzamide, N-(4-hydroxyphenyl)-4-octylbenzamide, 4-(4-octyl-1H-1,2,3-triazol-1-yl)phenol, and 2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethanol are slightly activating
Homo sapiens
additional information
design, synthesis, and evaluation of the potency of isoform-selective inhibitors of sphingosine kinases 1 and 2 using SK1 inhibitor RB-005 as lead compound, structure-activity relationships and molecular modeling of sphingosine kinase inhibitors, overview. No or poor inibition by 1-(4-methylphenethyl)piperidin-4-amine, 1-(4-octylphenethyl)piperidin-4-amine, 1-[2-[4-(4-pentyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol, and 1-[2-[4-(4-octyl-1H-1,2,3-triazol-1-yl)phenyl]ethyl]piperidin-4-ol, while potential inhibitors 1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol, 1-[2-(4-hexylphenyl)ethyl]piperidin-4-ol, [(2S)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-2-yl]methanol, and (4-hydroxypiperidin-1-yl)(4-octylphenyl)methanone are slightly activating
Homo sapiens
N,N-dimethylsphingosine
-
Homo sapiens
N-(4-hydroxyphenyl)-4-octylbenzamide
-
Homo sapiens
N-cyclohexyl-N-(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)acetamide
-
Homo sapiens
N-[4-(2-hydroxyethyl)phenyl]-4-octylbenzamide
-
Homo sapiens
PF-543
-
Homo sapiens
SLR080811
-
Homo sapiens
[(2R)-1-[2-(4-dodecylphenyl)ethyl]pyrrolidin-2-yl]methanol
-
Homo sapiens
[(2R)-1-[2-(4-methylphenyl)ethyl]pyrrolidin-2-yl]methanol
-
Homo sapiens
[(2R)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-2-yl]methanol
-
Homo sapiens
[(2S)-1-[2-(4-dodecylphenyl)ethyl]pyrrolidin-2-yl]methanol
-
Homo sapiens
[(2S)-1-[2-(4-octylphenyl)ethyl]pyrrolidin-2-yl]methanol
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ATP + D-erythro-sphingosine
Homo sapiens
-
ADP + D-erythro-sphingosine 1-phosphate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + D-erythro-sphingosine
-
738830
Homo sapiens
ADP + D-erythro-sphingosine 1-phosphate
-
-
-
?
General Information
General Information
Commentary
Organism
additional information
schematic model of the proposed mechanism of the phosphorylation of D-erythro-sphingosine catalyzed by isozyme SK1
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
additional information
schematic model of the proposed mechanism of the phosphorylation of D-erythro-sphingosine catalyzed by isozyme SK1
Homo sapiens
Other publictions for EC 2.7.1.91
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738428
Dickinson
Analysis of sphingosine kinase ...
Homo sapiens
Integr. Biol.
7
392-401
2015
-
-
-
-
-
-
-
-
-
-
-
4
-
3
-
-
-
-
-
1
-
-
6
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
6
-
2
-
-
-
2
-
-
-
-
2
4
-
-
-
738839
Patwardhan
Structure-activity relationshi ...
Homo sapiens
J. Med. Chem.
58
1879-1899
2015
-
-
-
-
-
-
36
-
3
-
-
2
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
48
-
-
-
-
-
2
-
-
-
-
62
48
-
3
-
-
2
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
737419
Muenzer
Sphingosine kinase 1 (Sphk1) n ...
Mus musculus, Mus musculus C57BL/6
Am. J. Physiol. Cell Physiol.
307
C920-C927
2014
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
737737
Baker
Structure and catalytic functi ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1831
139-146
2013
-
-
1
-
54
-
-
22
5
-
2
4
-
4
-
1
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
55
-
-
-
-
22
5
-
2
4
-
-
1
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
8
15
-
-
-
738592
Adada
Sphingosine kinase 1 regulates ...
Homo sapiens
J. Biol. Chem.
288
27667-27679
2013
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
738830
Baek
Structure-activity relationshi ...
Homo sapiens
J. Med. Chem.
56
9310-9327
2013
5
-
-
-
-
-
53
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
5
-
-
2
-
-
-
-
92
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
739718
Wang
Molecular basis of sphingosine ...
Homo sapiens
Structure
21
798-809
2013
-
1
1
1
3
-
1
3
-
1
-
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
2
-
-
-
1
-
-
-
-
1
1
1
1
3
-
-
1
-
3
-
1
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
2
-
-
-
-
-
2
2
-
-
-
722391
Lim
Inhibition kinetics and regula ...
Homo sapiens
Int. J. Biochem. Cell Biol.
44
1457-1464
2012
-
1
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723587
Gao
Characterization of isoenzyme- ...
Homo sapiens
PLoS ONE
7
e44543
2012
-
-
1
1
-
-
5
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
2
-
2
-
-
-
8
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
722709
Lim
FTY720 analogues as sphingosin ...
Homo sapiens
J. Biol. Chem.
286
18633-18640
2011
-
-
1
-
-
-
4
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
4
4
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723043
Cho
Sphingosine kinase 1 pathway i ...
Homo sapiens
J. Pineal Res.
51
87-93
2011
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
723077
Park
Sphingosine kinase 1 protects ...
Homo sapiens, Mus musculus
Kidney Int.
80
1315-1327
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
702084
Erez-Roman
Increased ceramide synthase 2 ...
Homo sapiens
Biochem. Biophys. Res. Commun.
391
219-223
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703090
Takuwa
S1P3-mediated cardiac fibrosis ...
Mus musculus
Cardiovasc. Res.
85
484-493
2010
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706681
Kono
Sphingosine kinase 1 regulates ...
Homo sapiens, Mus musculus
Pulm. Pharmacol. Ther.
23
36-42
2010
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
721418
Hengst
Enhancement of sphingosine kin ...
Homo sapiens
Arch. Biochem. Biophys.
494
23-31
2010
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722901
Siow
Intracellular localization of ...
Homo sapiens
J. Lipid Res.
51
2546-2559
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701617
Gamble
Sphingosine kinase-1 associate ...
Homo sapiens
Am. J. Pathol.
175
2217-2225
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701632
Wadgaonkar
Differential regulation of sph ...
Mus musculus
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L603-L613
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
701973
Lidington
The phosphorylation motif at s ...
Mesocricetus auratus
Arterioscler. Thromb. Vasc. Biol.
29
1916-1922
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701975
Hayashi
FHL-2 suppresses VEGF-induced ...
Homo sapiens
Arterioscler. Thromb. Vasc. Biol.
29
909-914
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
702037
Don
A lipid binding domain in sphi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
380
87-92
2009
7
-
1
-
1
-
6
3
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
7
-
1
-
-
1
-
-
6
-
3
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702089
Martin
Sphingosine kinase-1 mediates ...
Mus musculus
Biochem. Biophys. Res. Commun.
391
669-673
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
702432
Ter Braak
Ga(q)-mediated plasma membrane ...
Mus musculus
Biochim. Biophys. Acta
1791
357-370
2009
-
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
702597
Xiang
Discovery of novel sphingosine ...
Homo sapiens
Bioorg. Med. Chem. Lett.
19
6119-6121
2009
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702659
Foss
Synthesis and biological evalu ...
Homo sapiens, Mus musculus
Bioorg. Med. Chem.
17
6123-6136
2009
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703025
Kapitonov
Targeting sphingosine kinase 1 ...
Homo sapiens, Mus musculus
Cancer Res.
69
6915-6923
2009
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703087
Gellings Lowe
Sphingosine-1-phosphate and sp ...
Mus musculus
Cardiovasc. Res.
82
303-312
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703121
Limaye
The effects of markedly raised ...
Homo sapiens
Cell. Mol. Biol. Lett.
14
411-423
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703122
Limaye
Chronic increases in sphingosi ...
Homo sapiens
Cell. Mol. Biol. Lett.
14
424-441
2009
-
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703254
Li
Sphingosine kinase 1 is associ ...
Homo sapiens
Clin. Cancer Res.
15
1393-1399
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703463
Bergelin
Sphingosine kinase as an oncog ...
Homo sapiens
Endocrinology
150
2055-2063
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703464
Sukocheva
Restoring endocrine response i ...
Homo sapiens
Endocrinology
150
4484-4492
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703465
Gratschev
Sphingosine kinase as a regula ...
Rattus norvegicus
Endocrinology
150
5125-5134
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703613
Snider
A role for sphingosine kinase ...
Mus musculus
FASEB J.
23
143-152
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703616
Kawamori
Role for sphingosine kinase 1 ...
Homo sapiens, Mus musculus
FASEB J.
23
405-414
2009
-
2
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704041
Billich
Sphingosine kinase 1 is essent ...
Homo sapiens, Mus musculus
Int. J. Biochem. Cell Biol.
41
1547-1555
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
704044
Zebol
The CCT/TRiC chaperonin is req ...
Homo sapiens
Int. J. Biochem. Cell Biol.
41
822-827
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704071
Weigert
Sphingosine kinase 2 deficient ...
Homo sapiens
Int. J. Cancer
125
2114-2121
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704072
Sauer
Sphingosine kinase 1 inhibitio ...
Homo sapiens
Int. J. Cancer
125
2728-2736
2009
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
704152
Haberberger
Role of sphingosine kinase 1 i ...
Mus musculus
J. Allergy Clin. Immunol.
124
933-41.e1-9
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704592
Paugh
Interleukin-1 regulates the ex ...
Homo sapiens
J. Biol. Chem.
284
3408-3417
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
704945
Lai
Distinct roles of sphingosine ...
Mus musculus
J. Immunol.
183
2097-2103
2009
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704946
Pushparaj
Sphingosine kinase 1 is pivota ...
Mus musculus
J. Immunol.
183
221-227
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705438
Ren
Transforming growth factor-bet ...
Homo sapiens, Mus musculus
Kidney Int.
76
857-867
2009
-
2
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
705656
Schnitzer
Hypoxia enhances sphingosine k ...
Homo sapiens
Mol. Cancer Res.
7
393-401
2009
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705938
Nayak
Sphingosine kinase 1 regulates ...
Mus musculus
Neuroscience
166
132-144
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
706074
Kamada
Expression of sphingosine kina ...
Homo sapiens
Pathol. Int.
59
382-389
2009
-
1
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706448
Dayon
Sphingosine kinase-1 is centra ...
Homo sapiens
PLoS ONE
4
e8048
2009
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
684360
Nishiuma
Inhalation of sphingosine kina ...
Mus musculus
Am. J. Physiol. Lung Cell. Mol. Physiol.
294
L1085-L1093
2008
-
1
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685792
Paugh
A selective sphingosine kinase ...
Homo sapiens
Blood
112
1382-1391
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686643
Paugh
EGF regulates plasminogen acti ...
Homo sapiens
FASEB J.
22
455-465
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689845
Kim
Characterization of N,N,-dimet ...
Homo sapiens
Prostaglandins Other Lipid Mediat.
86
18-25
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702503
Hofmann
Sphingosine kinase 1 and 2 reg ...
Mus musculus
Biol. Chem.
389
1399-1407
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
702853
Li
Basal and angiopoietin-1-media ...
Homo sapiens, Mus musculus
Blood
111
3489-3497
2008
-
-
1
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
702951
Guo
Sphingosine kinase 1 gene tran ...
Homo sapiens
Br. J. Surg.
95
252-258
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703015
Ader
Sphingosine kinase 1: a new mo ...
Homo sapiens
Cancer Res.
68
8635-8642
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703085
Yan
Activation of sphingosine kina ...
Homo sapiens
Cardiovasc. Res.
78
308-314
2008
1
-
-
-
1
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703086
Jin
Ischaemic postconditioning pro ...
Mus musculus
Cardiovasc. Res.
79
134-140
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703218
Högenauer
Phosphorylation by sphingosine ...
Homo sapiens
ChemMedChem
3
1027-1029
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703236
Tauseef
Activation of sphingosine kina ...
Mus musculus
Circ. Res.
103
1164-1172
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
703252
Li
Clinical significance of sphin ...
Homo sapiens
Clin. Cancer Res.
14
6996-7003
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703466
Serrano-Sanchez
Signaling pathways involved in ...
Rattus norvegicus
Endocrinology
49
4669-4679
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703611
Gude
Apoptosis induces expression o ...
Homo sapiens
FASEB J.
22
2629-2638
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703697
Ikeda
Cyclooxygenase-2 induction by ...
Rattus norvegicus
FEBS Lett.
582
1147-1150
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703951
Wu
Sphingosine kinase 1/S1P recep ...
Mus musculus
Hum. Mol. Genet.
17
2257-2264
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704087
Sobue
Implications of sphingosine ki ...
Homo sapiens
Int. J. Hematol.
87
266-275
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704448
Anelli
Sphingosine kinase 1 is up-reg ...
Homo sapiens
J. Biol. Chem.
283
3365-3375
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
704795
Meacci
Sphingosine kinase activity is ...
Mus musculus
J. Cell. Physiol.
214
210-220
2008
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704989
Hong
K6PC-5, a direct activator of ...
Homo sapiens, Mus musculus
J. Invest. Dermatol.
128
2166-2178
2008
2
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705445
Bayerl
Sphingosine kinase 1 protein a ...
Homo sapiens
Leuk. Lymphoma
49
948-954
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705658
Pchejetski
Chemosensitizing effects of sp ...
Homo sapiens
Mol. Cancer Ther.
7
1836-1845
2008
-
1
1
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705684
Miller
Sphingosine kinases and sphing ...
Homo sapiens
Mol. Cell. Biol.
28
4142-4151
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705686
Maceyka
Filamin A links sphingosine ki ...
Homo sapiens
Mol. Cell. Biol.
28
5687-5697
2008
1
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
706008
Sobue
v-Src oncogene product increas ...
Mus musculus
Oncogene
27
6023-6033
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
1
1
2
-
-
706578
Hammad
Dual and distinct roles for sp ...
Mus musculus
Prostaglandins Other Lipid Mediat.
85
107-114
2008
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
671224
Leiber
Exogenous sphingosine 1-phosph ...
Rattus norvegicus
Am. J. Physiol.
292
C240-C250
2007
1
-
-
-
-
-
6
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
5
1
-
-
1
-
-
-
5
6
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671269
Kono
Sphingosine kinase 1 regulates ...
Homo sapiens, Mus musculus
Am. J. Respir. Cell Mol. Biol.
37
395-404
2007
2
-
-
-
-
-
2
-
-
-
-
-
-
5
-
-
-
-
-
8
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
3
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
10
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671356
Cuvillier
Sphingosine kinase-1 - a poten ...
Homo sapiens
Anticancer Drugs
18
105-110
2007
-
1
-
-
-
-
9
-
-
-
-
-
-
1
-
-
-
-
-
23
-
-
1
-
-
-
-
-
-
-
-
1
4
-
3
-
1
-
1
-
-
-
3
9
4
-
-
-
-
-
-
-
-
-
-
23
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671660
Choi
Sphingosine 1-phosphate and sp ...
Gallus gallus
Arch. Pharm. Res.
30
502-506
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672410
Francy
Sphingosine kinase 1 expressio ...
Homo sapiens
Biochim. Biophys. Acta
1769
253-265
2007
-
-
1
-
-
-
1
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672834
Klawitter
Extracellular nucleotides indu ...
Rattus norvegicus
Br. J. Pharmacol.
150
271-280
2007
-
-
-
-
-
-
2
-
-
-
1
-
-
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672942
Jin
A sphingosine kinase 1 mutatio ...
Mus musculus
Cardiovasc. Res.
76
41-50
2007
-
-
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673271
Ma
: Sphingosine kinase 1 partici ...
Homo sapiens
Diabetologia
50
891-900
2007
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673342
Doell
Prolactin upregulates sphingos ...
Homo sapiens
Endocr. Relat. Cancer
14
325-335
2007
2
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673473
Soldi
Sphingosine kinase 1 is a crit ...
Mus musculus
Exp. Cell Res.
313
3308-3318
2007
-
-
1
-
-
-
-
-
2
1
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
2
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674810
Don
Essential requirement for sphi ...
Homo sapiens
J. Biol. Chem.
282
15833-15842
2007
-
-
1
-
-
-
-
1
-
-
-
-
1
2
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674843
Kusner
The localization and activity ...
Homo sapiens, Mus musculus
J. Biol. Chem.
282
23147-23162
2007
4
-
-
-
4
-
2
-
2
-
4
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
4
-
-
2
-
4
-
-
2
-
-
2
-
4
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674904
Radeff-Huang
Tumor necrosis factor-alpha-st ...
Homo sapiens
J. Biol. Chem.
282
863-870
2007
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675516
Blondeau
Distribution of sphingosine ki ...
Mus musculus
J. Neurochem.
103
509-517
2007
-
-
-
-
-
-
1
-
-
1
-
-
-
3
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684883
Park
Cloning and characterization o ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
364
702-707
2007
-
-
1
-
-
-
2
-
-
3
1
1
-
3
-
-
-
-
-
6
-
-
4
1
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
2
2
-
-
3
1
1
-
-
-
-
-
6
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687057
Jung
Sphingosine kinase inhibitor s ...
Mus musculus
Immunology
121
533-544
2007
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687107
Jung
Sphingosine kinase inhibitor s ...
Mus musculus
Int. Immunol.
19
411-426
2007
-
-
-
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687479
Vessey
Dimethylsphingosine and FTY720 ...
Rattus norvegicus
J. Biochem. Mol. Toxicol.
21
273-279
2007
1
-
-
-
-
-
6
-
1
-
2
-
-
3
-
-
-
-
-
2
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
9
-
-
2
-
2
-
-
-
-
-
-
3
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689070
Kim
Suppression of osteoclastogene ...
Mus musculus
Mol. Pharmacol.
72
418-428
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689847
Leroux
Sphingolipids and the sphingos ...
Homo sapiens
Prostate
67
1699-1717
2007
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671669
Mulders
Sphingosine kinase-dependent a ...
Rattus norvegicus
Arterioscler. Thromb. Vasc. Biol.
26
2043-2048
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671745
Akao
High expression of sphingosine ...
Homo sapiens
Biochem. Biophys. Res. Commun.
342
1284-1290
2006
1
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672377
Huwiler
Histamine increases sphingosin ...
Homo sapiens
Biochim. Biophys. Acta
1761
367-376
2006
3
-
1
-
-
-
2
-
2
-
2
-
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
3
-
1
2
-
-
-
-
2
-
-
2
-
2
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672778
Zemann
Sphingosine kinase type 2 is e ...
Mus musculus
Blood
107
1454-1458
2006
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673354
Raymond
Endothelin-1 inhibits apoptosi ...
Rattus norvegicus
Endocrinology
147
5873-5882
2006
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673513
Roviezzo
Essential requirement for sphi ...
Rattus norvegicus
FASEB J.
20
340-342
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673516
Keller
Sphingosine kinase functionall ...
Mesocricetus auratus
FASEB J.
20
702-704
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673671
Taha
Sphingosine kinase-1 is cleave ...
Homo sapiens, Mus musculus, Rattus norvegicus
FEBS Lett.
580
6047-6054
2006
-
-
-
-
5
-
-
-
-
-
1
-
-
3
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
5
-
-
-
-
-
-
-
1
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674084
Leclerq
Cellular signalling by sphingo ...
Homo sapiens, Mus musculus
IUBMB Life
58
467-472
2006
-
-
1
-
-
-
-
-
3
-
2
-
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
3
-
-
-
-
-
-
-
5
-
2
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674380
Taha
Sphingosine kinase: biochemica ...
Homo sapiens, Rattus norvegicus
J. Biochem. Mol. Biol.
39
113-131
2006
7
-
-
-
-
-
10
5
4
4
-
-
-
3
-
-
-
-
-
8
-
-
10
-
-
-
-
-
2
-
-
2
-
-
-
14
-
-
3
-
-
-
-
10
-
5
6
4
-
-
-
-
-
-
-
9
-
-
10
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
674746
Kihara
Mouse sphingosine kinase isofo ...
Mus musculus
J. Biol. Chem.
281
4532-4539
2006
-
-
1
-
1
-
-
-
1
-
3
-
-
4
-
-
-
-
-
8
-
-
2
2
-
-
-
-
-
-
-
1
-
-
-
-
-
2
2
-
2
-
-
-
-
-
2
-
4
-
-
-
-
-
-
16
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675032
Zhi
Sphingosine kinase 1 regulates ...
Homo sapiens
J. Cell. Physiol.
208
109-115
2006
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675972
Kohno
Intracellular role for sphingo ...
Homo sapiens, Mus musculus
Mol. Cell. Biol.
26
7211-7223
2006
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661329
Kim
Synthesis and evaluation of sp ...
Homo sapiens
Bioorg. Med. Chem.
13
3475-3485
2005
-
-
1
-
-
-
17
-
-
1
-
1
-
2
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
17
-
-
-
1
-
1
-
-
-
-
-
1
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
661509
Kee
Sphingosine kinase signalling ...
Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Tetrahymena pyriformis
Clin. Exp. Pharmacol. Physiol.
32
153-161
2005
-
-
7
-
-
-
4
-
10
-
-
15
-
9
-
-
1
7
-
29
-
-
22
-
-
-
-
-
-
-
-
7
-
-
-
-
-
7
7
-
-
-
-
4
-
-
10
-
-
15
-
-
-
1
-
29
-
-
22
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661614
Min
Sphingosine kinase regulates t ...
Dictyostelium discoideum
Eukaryot. Cell
4
178-189
2005
-
-
1
-
1
-
-
-
2
1
-
2
-
3
-
-
-
-
-
1
1
-
2
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
1
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
661860
Baumruker
The role of sphingosine and ce ...
Homo sapiens, Mus musculus
Immunol. Lett.
96
175-185
2005
8
1
2
-
-
-
2
2
6
-
-
5
-
2
-
1
-
1
-
12
1
-
14
1
-
-
-
-
-
-
-
3
-
-
-
8
1
2
3
-
-
-
-
2
-
2
6
-
-
5
-
-
1
-
-
12
1
-
14
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
662564
Matsumoto
Localization of sphingosine ki ...
Mus musculus
J. Histochem. Cytochem.
53
243-247
2005
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663137
Coursol
Arabidopsis sphingosine kinase ...
Arabidopsis thaliana
Plant Physiol.
137
724-737
2005
2
-
1
-
-
-
3
1
2
1
-
2
-
3
-
-
-
-
-
4
-
-
8
-
1
-
-
-
-
-
-
1
-
-
-
2
-
1
1
-
-
-
-
3
-
1
2
1
-
2
-
-
-
-
-
4
-
-
8
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
660694
Roberts
An assay for sphingosine kinas ...
Homo sapiens
Anal. Biochem.
331
122-129
2004
3
-
1
-
-
-
-
1
-
1
-
-
-
3
-
-
-
-
-
-
3
-
6
-
1
-
-
-
1
-
-
1
-
-
-
5
-
2
2
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
3
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
660975
Meacci
Sphingosine kinase activity is ...
Homo sapiens
Biochem. J.
381
655-663
2004
-
-
1
-
-
-
-
-
4
-
-
2
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661750
Yokota
Asp177 in C4 domain of mouse s ...
Mus musculus
FEBS Lett.
578
106-110
2004
1
-
1
-
6
-
-
10
-
1
-
1
-
2
-
-
-
1
-
-
1
-
2
-
1
-
-
-
1
-
-
1
-
-
-
1
-
1
1
-
6
-
-
-
-
10
-
1
-
1
-
-
-
-
-
-
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662191
Herr
Characterization of the Drosop ...
Drosophila melanogaster
J. Biol. Chem.
279
12685-12694
2004
-
-
1
-
1
-
-
-
1
-
-
6
-
7
-
-
-
-
-
2
-
-
10
-
1
-
-
-
1
-
-
1
-
-
-
-
-
2
2
-
2
-
-
-
-
-
2
-
-
6
-
-
-
-
-
4
-
-
10
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
660860
Fukuda
Distribution of sphingosine ki ...
Mus musculus
Biochem. Biophys. Res. Commun.
309
155-160
2003
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
15
7
-
2
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
15
7
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
662167
Billich
Phosphorylation of the immunom ...
Homo sapiens, Mus musculus
J. Biol. Chem.
278
47408-47415
2003
-
-
2
-
-
-
-
9
3
-
-
4
-
7
-
-
-
-
-
10
2
-
11
-
2
-
-
-
2
-
-
2
-
-
-
-
-
4
4
-
-
-
-
-
-
18
6
-
-
4
-
-
-
-
-
20
4
-
11
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
492166
Xia
Sphingosine kinase interacts w ...
Homo sapiens
J. Biol. Chem.
277
7996-8003
2002
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492167
Ancellin
Extracellular export of sphing ...
Mus musculus
J. Biol. Chem.
277
6667-6675
2002
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492168
Pitson
The nucleotide-binding site of ...
Homo sapiens
J. Biol. Chem.
277
49545-49553
2002
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492169
Vann
Involvement of sphingosine kin ...
Mus musculus
J. Biol. Chem.
277
12649-12656
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492172
Liu
Sphingosine kinases: a novel f ...
Mammalia, plant, Saccharomyces cerevisiae
Prog. Nucleic Acid Res. Mol. Biol.
71
493-511
2002
-
-
3
-
-
-
-
-
-
-
-
3
-
7
-
-
-
3
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492175
Hait
Lcb4p sphingoid base kinase lo ...
Saccharomyces cerevisiae
FEBS Lett.
532
97-102
2002
-
-
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492178
Kono
Inhibition of recombinant sphi ...
Homo sapiens
J. Antibiot.
55
99-103
2002
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
3
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492182
Labesse
Diacylglyceride kinases, sphin ...
Homo sapiens
Trends Biochem. Sci.
27
273-275
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492173
Kleuser
Stimulation of nuclear sphingo ...
Homo sapiens
FEBS Lett.
503
85-90
2001
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492174
Murate
Cell type-specific localizatio ...
Homo sapiens
J. Histochem. Cytochem.
49
845-855
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492183
Pitson
A point mutant of human sphing ...
Homo sapiens
FEBS Lett.
509
169-173
2001
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492164
Pitson
Human sphingosine kinase: puri ...
Homo sapiens
Biochem. J.
350
429-441
2000
-
-
1
-
-
-
6
3
-
3
-
-
-
3
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
1
-
-
3
-
-
-
-
1
-
-
-
-
-
6
3
3
-
3
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
492170
Liu
Molecular cloning and function ...
Homo sapiens, Mus musculus
J. Biol. Chem.
275
19513-19520
2000
-
-
2
-
-
-
5
1
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
1
-
2
-
-
2
-
-
-
-
2
5
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
492176
Melendez
Human sphingosine kinase: mole ...
Homo sapiens
Gene
251
19-26
2000
-
-
1
-
-
-
2
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492180
Nava
Functional characterization of ...
Homo sapiens
FEBS Lett.
473
81-84
2000
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492165
Lanterman
-
Characterization of sphingosin ...
Saccharomyces cerevisiae
Biochem. J.
332
525-531
1998
-
-
-
-
1
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
492171
Olivera
Purification and characterizat ...
Rattus norvegicus
J. Biol. Chem.
273
12576-12583
1998
-
-
-
-
-
-
2
2
-
1
1
-
-
2
-
-
1
-
-
2
-
-
1
1
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
2
-
1
1
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
492179
Olivera
Sphingosine kinase. Assay and ...
Mammalia, Saccharomyces cerevisiae
Methods Mol. Biol.
105
233-242
1998
-
-
1
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492181
Choi
Calcium mobilization via sphin ...
Rattus norvegicus
Nature
380
634-636
1996
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492159
Mazurek
Regulatory effect of phorbol e ...
Mus musculus
Biochem. Biophys. Res. Commun.
198
1-9
1994
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492177
Olivera
Sphingosine kinase from Swiss ...
Homo sapiens
Anal. Biochem.
223
306-312
1994
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492160
Buehrer
Inhibition of sphingosine kina ...
Rattus norvegicus
J. Biol. Chem.
267
3154-3159
1992
-
-
-
-
-
-
3
-
1
-
-
1
-
3
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492162
Louie
Sphingolipid base metabolism. ...
Bos taurus
J. Biol. Chem.
251
4557-4564
1976
-
-
-
-
-
2
-
-
-
1
1
-
-
2
-
-
1
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
-
-
-
1
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
390630
Stoffel
The metabolism of sphingosine ...
Tetrahymena pyriformis
Hoppe-Seyler's Z. Physiol. Chem.
355
61-74
1974
-
-
-
-
-
-
-
2
1
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
492156
Stoffel
Sphingosine kinase in blood pl ...
Homo sapiens, Sus scrofa
Hoppe-Seyler's Z. Physiol. Chem.
354
562-566
1973
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
492158
Stoffel
Properties and specificities o ...
Homo sapiens, Sus scrofa
Hoppe-Seyler's Z. Physiol. Chem.
354
1311-1316
1973
-
-
-
-
-
-
6
2
3
2
-
-
-
2
-
-
-
-
-
2
-
1
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
2
3
2
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
492161
Keenan
Sphingolipid base phosphorylat ...
Tetrahymena pyriformis
Biochim. Biophys. Acta
270
383-396
1972
1
-
-
-
-
-
1
-
1
3
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
492163
Hirschberg
Enzymatic formation of dihydro ...
Rattus norvegicus
J. Biol. Chem.
245
3084-3090
1970
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-