Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NYA1 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
SK1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | expression of isoform SK1 artificially targeted to the endoplasmic reticulum or without targeting signal, but surprisingly not plasma membrane-targeted SK1, results in a dramatic increase in the phosphorylation of dihydrosphingosine. Knockdown of endogenous SK1 diminishes both dihydrosphingosine-1-phosphate and sphinganine 1-phosphate levels. Sphinganine 1-phosphate produced at the plasma membrane is degraded to the same extent as that produced in the endoplasmic reticulum indicating that there is an efficient mechanism for the transport of sphinganine 1-phosphate. Sphinganine 1-phosphate degradation is primarily driven by lyase cleavage of sphinganine 1-phosphate | Homo sapiens |