Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
OE-33 cell | - |
Homo sapiens | - |
SEG-1 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | SphK1 siRNA reduces both the SphK1 mRNA and the protein levels by 70% and has no effect on SphK2 expression. The SphK2 siRNA is equally specific but somewhat less efficient at reducing SphK2 expression. Decreasing SphK1expression significantly decreases both TGFbeta-induced chemotactic migration and invasion, whereas decreasing SphK2 expression inhibits chemotactic migration less effectively and has no effect on chemotactic invasion. Decreased expression of SphKs also inhibits TGFbeta activation of ERK1/2. TGFbeta activation of sphingosine kinases and formation of sphinmgosine 1-phosphate contribute to non-Smad signaling | Homo sapiens |