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Literature summary for 2.7.1.91 extracted from

  • Paugh, B.S.; Bryan, L.; Paugh, S.W.; Wilczynska, K.M.; Alvarez, S.M.; Singh, S.K.; Kapitonov, D.; Rokita, H.; Wright, S.; Griswold-Prenner, I.; Milstien, S.; Spiegel, S.; Kordula, T.
    Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells (2009), J. Biol. Chem., 284, 3408-3417.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
U-373MG cell
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Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens the expression of IL-1 correlates with the expression of SphK1 in glioblastoma cells. IL-1 up-regulates SphK1 mRNA levels, protein expression, and activity in both primary human astrocytes and various glioblastoma cell lines, it does not affect SphK2 expression. The IL-1-induced SphK1 up-regulation can be blocked by the inhibition of c-Jun N-terminal kinase, the overexpression of the dominant-negative c-Jun(TAM67), and the down-regulation of c-Jun expression by small interference RNA. Activation of SphK1 expression by IL-1 occurs on the level of transcription and is mediated via a novel AP-1 element located within the first intron of the sphk1 gene up