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Literature summary for 2.7.1.91 extracted from

  • Billich, A.; Urtz, N.; Reuschel, R.; Baumruker, T.
    Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells (2009), Int. J. Biochem. Cell Biol., 41, 1547-1555.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
thrombin stimulation of the lung epithelial cell line A-549 by thrombin leads to transient increase of SPHK1 activity and elevation of intracellular sphingosine 1-phosphate, abrogation of this stimulation by SPHK1-specific siRNA, pharmacological inhibition, or expression of a dominant-negative SPHK1 mutant blocks the response to thrombin. PAR-1 or thrombin-induced cytokine production and adhesion factor expression of human umbilical vein endothelial cells is also dependent on SPHK1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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endothelial cell dermal microvascular endothelial cell Mus musculus
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HUVEC cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function in SPHK1-deficient mice, absence of the enzyme abrogates MCP-1 production induced in dermal microvascular endothelial cells upon treatment with thrombin or PAR-1 activating peptide Mus musculus
physiological function stimulation of the lung epithelial cell line A-549 by thrombin leads to transient increase of SPHK1 activity and elevation of intracellular sphingosine 1-phosphate, abrogation of this stimulation by SPHK1-specific siRNA, pharmacological inhibition, or expression of a dominant-negative SPHK1 mutant blocks the response to thrombin. PAR-1 or thrombin-induced cytokine production and adhesion factor expression of human umbilical vein endothelial cells is also dependent on SPHK1 Homo sapiens