Literature summary for 2.7.1.91 extracted from

Bergelin, N.; Blom, T.; Heikkilae, J.; Loef, C.; Alam, C.; Balthasar, S.; Slotte, J.P.; Hinkkanen, A.; Toernquist, K.
Sphingosine kinase as an oncogene: autocrine sphingosine 1-phosphate modulates ML-1 thyroid carcinoma cell migration by a mechanism dependent on protein kinase C-alpha and ERK1/2 (2009), Endocrinology, 150, 2055-2063.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ML-1 cell	follicular thyroid cell	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	overexpression of isoform Sk1 in ML-1 cells results in increased expression of sphingosine 1-phosphate, which can be attenuated by inhibiting Sk1 activity and an ATP-binding cassette transporter. Overexpression of Sk1 enhances serum-induced migration of ML-1 cells. Inhibition of protein kinase Calpha attenuates migration in Sk1 overexpressing cells. Overexpressing cells show an impaired adhesion, slower cell growth, and up-regulation of ERK1/2 phosphorylation	Homo sapiens

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Release 2023.1 (January 2023)