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Literature summary for 2.7.1.91 extracted from

  • Limaye, V.; Xia, P.; Hahn, C.; Smith, M.; Vadas, M.A.; Pitson, S.M.; Gamble, J.R.
    Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells (2009), Cell. Mol. Biol. Lett., 14, 424-441.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the synovial fluid levels of sphingosine 1-phosphate are significantly higher in patients with rheumatoid arthritis than in those with osteoarthritis. Small chronic increases in SK1 activity in the endothelial cells enhance the ability of the cells to support inflammation and undergo angiogenesis, and sensitize the cells to inflammatory cytokines. The SK1 signaling pathway is activated in rheumatoid arthritis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
3- to 5fold overexpression in HUVEC cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
G82D over-expression inhibits the TNF-induced vascular cell adhesion molecule VCAM-1 and E selectin and inhibits PMN adhesion Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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General Information

General Information Comment Organism
physiological function HUVEC cells with 3- to 5fold overexpression of isoform SK1 show an enhanced migratory capacity and a stimulated rate of capillary tube formation. The cells show constitutive activation, and a more augmented vascular cell adhesion molecule VCAM-1 and E selectin response to TNF compared with empty vector control cells Homo sapiens